Next Article in Journal
Potentiometry, Nanostructured Materials and the Emergence of Paradigm-Shifting Analytical Platforms
Previous Article in Journal
A Monitoring Approach to Smart Infrastructure Management
Article Menu
Issue 10 (NPCPT 2017) cover image

Export Article

Open AccessAbstract
Proceedings 2017, 1(10), 976;

Resveratrol in Cancer Prevention and Treatment: Focusing on Molecular Targets and Mechanism of Action

Department of Biochemistry, Biophysics and General Pathology, University of Campania “L. Vanvitelli”, Naples 80138, Italy
Presented at the 2nd International Conference on Natural Products for Cancer Prevention and Therapy, Kayseri, Turkey, 8–11 November 2017.
Published: 22 November 2017
PDF [134 KB, uploaded 27 December 2017]


Resveratrol (3,5,4′-trihydroxystilbene) is a phytoalexin occurring in grapes, red wines, peanuts, berries and other vegetables that has been reported to provide protection against several human diseases, including metabolic diseases and cancer. More than one thousand preclinical investigations, performed in vitro and in animal models, indicate that resveratrol efficaciously affects the development and progression of various tumors such as breast, lung, prostate and colon carcinomas, leukemias, skin tumors and melanomas. On this basis, resveratrol and its derivatives are under investigation in humans as cancer chemopreventive and/or chemotherapeutic agents. Resveratrol mechanism of action has been widely studied in cancer cells and in experimental models of senescence, inflammation, obesity and metabolic diseases. Its molecular targets act at different levels: (1) specific molecular pathways (like NF-B, MAPK/JNK/p38 Kinase, PKC, PI3K-AKT and several others); (2) epigenetic control of gene transcription through sirtuin activation; (3) cell division cycle and differentiation; (4) apoptosis and autophagy; (5) cellular redox homeostasis. In addition, the phytoalexin might modify microbiome composition and mimic hormone activity. Particularly, we recently reported that the molecule is able to substitute insulin in adipogenesis induction of mesenchymal stromal cells derived from human bone marrow. The relevance of these mechanisms and their translation in clinical therapy will be discussed.
Keywords: resveratrol; cancer; molecular targets resveratrol; cancer; molecular targets
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

Share & Cite This Article

MDPI and ACS Style

Borriello, A. Resveratrol in Cancer Prevention and Treatment: Focusing on Molecular Targets and Mechanism of Action. Proceedings 2017, 1, 976.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Metrics

Article Access Statistics



[Return to top]
Proceedings EISSN 2504-3900 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top