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Proceedings 2017, 1(10), 1043;

Anticancer Activity of Centaurea babylonica L.

Department of Pharmaceutical Botany, Graduate School of Health Sciences, Anadolu University, Eskişehir 26470, Turkey
Department of Biochemistry, Faculty of Pharmacy, Anadolu University, Eskişehir 26470, Turkey
Department of Pharmacognosy, Faculty of Pharmacy, Anadolu University, Eskişehir 26470, Turkey
Presented at the 2nd International Conference on Natural Products for Cancer Prevention and Therapy, Kayseri, Turkey, 8–11 November 2017.
Author to whom correspondence should be addressed.
Published: 17 November 2017
PDF [167 KB, uploaded 17 November 2017]


Today, new agents are required to protect from cancer due to the side effects and some deficiencies in the medical drugs used to treat cancer. Because of this reason, active substances used in drugs which is herbal origin of the treatment of tumors as an alternative agent studies continues to increase. It has been determined that some species belonging to the genus Centaurea have cytotoxic effect. Centaurea babylonica plant has not been performed on cytotoxicity before. Plant was collected from Çamlıyayla district of Mersin province. Methanol extract was prepared from the plant and cytotoxicity tests of the extracts were performed. In vitro cytotoxic effects of extraneous material obtained from the supernatant were determined by MTT assay using C6 (Glioma), A549 (human lung adenocarcinoma) and MCF-7 (human breast cancer) cell lines. Cytotoxic effect was found high in methanol extract. In the DNA synthesis inhibition test of extract, the extract was found to show a high inhibition from the cisplatin used as a control. The 3T3 test, in which the methanol extract showed no toxic effect on healthy fibroblast cells, was supported.
Keywords: Centaurea babylonica; methanol extract; cytotoxicity Centaurea babylonica; methanol extract; cytotoxicity
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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Dündar, E.; Çiftçi, G.A.; Altıntaş, A. Anticancer Activity of Centaurea babylonica L.. Proceedings 2017, 1, 1043.

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