Cytotoxic Activity of Achillea coarctata Poir. Extract †
1
Biology Department, Science Faculty, Erciyes University, Kayseri 38000, Turkey
2
Graduate School Natural Applied Science, Erciyes University, Kayseri 38000, Turkey
*
Author to whom correspondence should be addressed.
†
Presented at the 2nd International Conference on Natural Products for Cancer Prevention and Therapy, Kayseri, Turkey, 8–11 November 2017.
Proceedings 2017, 1(10), 1039; https://doi.org/10.3390/proceedings1101039
Published: 17 November 2017
(This article belongs to the Proceedings of Proceedings of the 2nd International Conference on Natural Products for Cancer Prevention and Therapy)
Abstract
:Achillea L. (Asteraceae) is a traditional medicinal herb which contains different phenol and flavonoid compounds that are responsible for Achillea pharmacological effects. Turkey is one of the most important centers of diversity for the genus Achillea in the world. The aim of this research was the investigation of the cytotoxic activity of A. coarctata Poir. extract on a human breast cancer cell line (MCF-7). The cytotoxic activity of the extract on the MCF-7 cell line and mouse embryo fibroblast cells (NIH/3T3) were evaluated by 3-(4,5-dimethyl thiazol-2-yl)-2,5-diphynyl tetrazolium bromide (MTT) assay. The extract has cytotoxic activity on MCF-7 cell line with IC50 values 37.39 and 33.98 µg/mL after 24 and 48 h treatments, respectively. The results showed that the extract inhibited significantly MCF-7 cell. Further investigation is required to assess the cytotoxic potential of the extract in cancer therapy, and to isolation and purification of bioactive compounds.
Acknowledgments
This work was supported by the Research Fund of the University of Erciyes. Project number is FYL-2017-7077.
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MDPI and ACS Style
Albayrak, S.; Silahtarlıoğlu, N. Cytotoxic Activity of Achillea coarctata Poir. Extract. Proceedings 2017, 1, 1039. https://doi.org/10.3390/proceedings1101039
AMA Style
Albayrak S, Silahtarlıoğlu N. Cytotoxic Activity of Achillea coarctata Poir. Extract. Proceedings. 2017; 1(10):1039. https://doi.org/10.3390/proceedings1101039
Chicago/Turabian StyleAlbayrak, Sevil, and Nurcan Silahtarlıoğlu. 2017. "Cytotoxic Activity of Achillea coarctata Poir. Extract" Proceedings 1, no. 10: 1039. https://doi.org/10.3390/proceedings1101039
