Zambia: A Narrative Review of Success and Challenges in Lymphatic Filariasis Elimination
Abstract
:1. Introduction
2. Methods
3. Lymphatic Filariasis in Zambia
4. Historical Government Policies
Year | Pop. Requiring MDA (mil.) | Total IUs | IUs with MDA | IUs MDA Achieving >65% Coverage (%) | Geographical Coverage (%) | Pop. in Active MDAs (mil.) | Pop. Treated by MDA (mil.) | Program Coverage (%) | National Coverage (%) |
---|---|---|---|---|---|---|---|---|---|
2015 | 11.6 | 85 | 83 | 92.8 | 97.65 | 11.6 | 10.7 | 92% | 92% |
2016 | 11.3 | 85 | 85 | 97.7 | 100 | 11.3 | 10.4 | 92.10% | 92% |
2017 | 11.3 | 85 | - | - | - | - | - | - | - |
2018 | 12.0 | 85 | 69 | 100 | 100 | 10.9 | 11.2 | 102% | 93% |
2019 | 12.0 | 85 | - | - | - | - | - | - | - |
2020 | 13.2 | 85 | 35 | 97.1 | 41.2 | 4.64 | 4.88 | 105% | 37% |
2021 | 13.2 | 85 | 35 | 97.1 | 41.2 | 4.64 | 4.88 | 105% | 37% |
5. The COVID-19 Era and Beyond
6. Ongoing and Future Challenges
6.1. Climate Change
6.2. Health Systems
7. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
- WHO. Progress Report 2000–2009 and Strategic Plan 2010–2020 of the Global Programme to Eliminate Lymphatic Filariasis: Halfway towards Eliminating Lymphatic Filariasis; WHO: Geneva, Switzerland, 2010. [Google Scholar]
- WHO. Monitoring and Epidemiological Assessment of Mass Drug Administration in the Global Programme to Eliminate Lymphatic Filariasis: A Manual for National Elimination Programmes; World Health Organization: Geneva, Switzerland, 2011. [Google Scholar]
- WHO. Bangladesh Eliminates Lymphatic Filariasis. World Health Organization. 2023. Available online: https://www.who.int/southeastasia/news/detail/13-05-2023-bangladesh-eliminates-lymphatic-filariasis (accessed on 2 July 2023).
- WHO. Global programme to eliminate lymphatic filariasis: Progress report, 2014. Wkly. Epidemiol. Rec. 2015, 90, 489–504. [Google Scholar]
- Cromwell, E.A.; Schmidt, C.A.; Kwong, K.T.; Pigott, D.M.; Mupfasoni, D.; Biswas, G.; Shirude, S.; Hill, E.; Donkers, K.M.; Abdoli, A.; et al. The global distribution of lymphatic filariasis, 2000–2018: A geospatial analysis. Lancet Glob. Health 2020, 8, e1186–e1194. [Google Scholar] [CrossRef] [PubMed]
- WHO. Global programme to eliminate lymphatic filariasis: Progress report, 2021. Wkly. Epidemiol. Rec. 2022, 97, 513–524. [Google Scholar]
- Ministry of Health. Elimination of Neglected Tropical Diseases National Masterplan 2019–2023; Ministry of Health: Lusaka, Zambia, 2019.
- 2022–2026 National Health Strategic Plan; Ministry of Health: Lusaka, Zambia, 2023.
- Engels, D.; Zhou, X.-N. Neglected tropical diseases: An effective global response to local poverty-related disease priorities. Infect. Dis. Poverty 2020, 9, 9–17. [Google Scholar] [CrossRef] [PubMed]
- Mathew, C.G.; A Bettis, A.; Chu, B.K.; English, M.; Ottesen, E.A.; Bradley, M.H.; Turner, H.C. The Health and Economic Burdens of Lymphatic Filariasis Prior to Mass Drug Administration Programs. Clin. Infect. Dis. 2020, 70, 2561–2567. [Google Scholar] [CrossRef]
- WHO. Investing to Overcome the Global Impact of Neglected Tropical Diseases: Third WHO Report on Neglected Tropical Diseases; World Health Organization: Geneva, Switzerland, 2015. [Google Scholar]
- WHO. Defeating Neglected Tropical Diseases: Progress, Challenges and Opportunities; World Health Organization: Geneva, Switzerland, 2019. [Google Scholar]
- Deribe, K.; Bakajika, D.K.; Zoure, H.M.; Gyapong, J.O.; Molyneux, D.H.; Rebollo, M.P. African regional progress and status of the programme to eliminate lymphatic filariasis: 2000–2020. Int. Health 2020, 13 (Suppl. S1), S22–S27. [Google Scholar] [CrossRef]
- Masaninga, F.; Chanda, E.; Chanda-Kapata, P.; Hamainza, B.; Masendu, H.T.; Kamuliwo, M.; Kapelwa, W.; Chimumbwa, J.; Govere, J.; Otten, M.; et al. Review of the malaria epidemiology and trends in Zambia. Asian Pac. J. Trop. Biomed. 2013, 3, 89–94. [Google Scholar] [CrossRef]
- Mackenzie, C.D.; Mante, S. Caring for patients in the global programme to eliminate lymphatic filariasis. Int. Health 2020, 13 (Suppl. S1), S48–S54. [Google Scholar] [CrossRef]
- Zeldenryk, L.M.; Gray, M.; Speare, R.; Gordon, S.; Melrose, W. The Emerging Story of Disability Associated with Lymphatic Filariasis: A Critical Review. PLoS Negl. Trop. Dis. 2011, 5, e1366. [Google Scholar] [CrossRef]
- Zulu, J.M.; Maritim, P.; Silumbwe, A.; Halwiindi, H.; Mubita, P.; Sichone, G.; Mpandamabula, C.H.H.; Shamilimo, F.; Michelo, C. Unlocking Trust in Community Health Systems: Lessons From the Lymphatic Filariasis Morbidity Management and Disability Prevention Pilot Project in Luangwa District, Zambia. Int. J. Health Policy Manag. 2021, 11, 80–89. [Google Scholar] [CrossRef]
- Vos, T.; Lim, S.S.; Abbafati, C.; Abbas, K.M.; Abbasi, M.; Abbasifard, M.; Abbasi-Kangevari, M.; Abbastabar, H.; Abd-Allah, F.; Abdelalim, A.; et al. Global burden of 369 diseases and injuries in 204 countries and territories, 1990–2019: A systematic analysis for the Global Burden of Disease Study 2019. Lancet 2020, 396, 1204–1222. [Google Scholar] [CrossRef] [PubMed]
- WHO. Lymphatic Filariasis: Managing Morbidity and Prevention Disability: An Aide-Mémoire for National Programme Managers, 2nd ed.; World Health Organization: Geneva, Switzerland, 2021. [Google Scholar]
- Gardon, J.; Gardon-Wendel, N.; Demanga-Ngangue Kamgno, J.; Chippaux, J.P.; Boussinesq, M. Serious reactions after mass treatment of onchocerciasis with ivermectin in an area endemic for Loa loa infection. Lancet 1997, 350, 18–22. [Google Scholar] [CrossRef] [PubMed]
- Stocks, M.E.; Freeman, M.C.; Addiss, D.G. The Effect of Hygiene-Based Lymphedema Management in Lymphatic Filariasis-Endemic Areas: A Systematic Review and Meta-analysis. PLoS Negl. Trop. Dis. 2015, 9, e0004171. [Google Scholar] [CrossRef] [PubMed]
- Buckley, J.J.C. A Helminthological Survey in Northern Rhodesia. J. Helminthol. 1946, 21, 111–174. [Google Scholar] [CrossRef]
- Barclay, R. Filariasis in the Luangwa Basin. Med. J. Zamb. 1971, 5, 201–203. [Google Scholar]
- Hira, P. Bancroftian filariasis in Zambia. Ann. Trop. Med. Parasitol. 1975, 69, 521–522. [Google Scholar] [CrossRef]
- Hira, P. Bancroftian filariasis. An autochthonous case in Zambia. Med. J. Zamb. 1976, 10, 160–164. [Google Scholar]
- Hira, P. Wuchereria bancrofti: The staining of the microfilarial sheath in giemsa and haematoxyl in for diagnosis. Med. J. Zamb. 1977, 11, 93–96. [Google Scholar]
- Matondo, A.; Lungu, A. Lymphatic filariasis in a Zambian woman: A case report. Zamb. J. Med. Health Sci. 1998, 2, 55–56. [Google Scholar]
- Kaile, T. Filariasis presenting as pyrexia of unknown origin in a young Zambian adult: A case report. Zamb. J. Med. Health Sci. 1998, 2, 2–3. [Google Scholar]
- Mwase, E.T.; Stensgaard, A.-S.; Nsakashalo-Senkwe, M.; Mubila, L.; Mwansa, J.; Songolo, P.; Shawa, S.T.; Simonsen, P.E. Mapping the Geographical Distribution of Lymphatic Filariasis in Zambia. PLoS Negl. Trop. Dis. 2014, 8, e2714. [Google Scholar] [CrossRef] [PubMed]
- Collyer, B.S.; Irvine, M.A.; Hollingsworth, T.D.; Bradley, M.; Anderson, R.M. Defining a prevalence level to describe the elimination of Lymphatic Filariasis (LF) transmission and designing monitoring & evaluating (M&E) programmes post the cessation of mass drug administration (MDA). PLoS Negl. Trop. Dis. 2020, 14, e0008644. [Google Scholar] [CrossRef]
- Wiebe, A.; Longbottom, J.; Gleave, K.; Shearer, F.M.; Sinka, M.E.; Massey, N.C.; Cameron, E.; Bhatt, S.; Gething, P.W.; Hemingway, J.; et al. Geographical distributions of African malaria vector sibling species and evidence for insecticide resistance. Malar. J. 2017, 16, 85. [Google Scholar] [CrossRef] [PubMed]
- Coleman, M.; Hemingway, J.; Gleave, K.A.; Wiebe, A.; Gething, P.W.; Moyes, C.L. Developing global maps of insecticide resistance risk to improve vector control. Malar. J. 2017, 16, 86. [Google Scholar] [CrossRef] [PubMed]
- Chanda, E.; Hemingway, J.; Kleinschmidt, I.; Rehman, A.M.; Ramdeen, V.; Phiri, F.N.; Coetzer, S.; Mthembu, D.; Shinondo, C.J.; Chizema-Kawesha, E.; et al. Insecticide resistance and the future of malaria control in Zambia. PLoS ONE 2011, 6, e24336. [Google Scholar] [CrossRef] [PubMed]
- Kamuliwo, M.; Chanda, E.; Haque, U.; Mwanza-Ingwe, M.; Sikaala, C.; Katebe-Sakala, C.; Mukonka, V.M.; Norris, D.E.; Smith, D.L.; Glass, G.E.; et al. The changing burden of malaria and association with vector control interventions in Zambia using district-level surveillance data, 2006–2011. Malar. J. 2013, 12, 437. [Google Scholar] [CrossRef]
- Shawa, S.T.; Mwase, E.T.; Pedersen, E.M.; Simonsen, P.E. Lymphatic filariasis in Luangwa District, South-East Zambia. Parasites Vectors 2013, 6, 299. [Google Scholar] [CrossRef]
- Maritim, P.; Silumbwe, A.; Zulu, J.M.; Sichone, G.; Michelo, C. Health beliefs and health seeking behavior towards lymphatic filariasis morbidity management and disability prevention services in Luangwa District, Zambia: Community and provider perspectives. PLoS Negl. Trop. Dis. 2021, 15, e0009075. [Google Scholar] [CrossRef]
- CDC. Recommendations of the International Task Force for Disease Eradication. MMWR Recomm. Rep. 1993, 42, 1–38. [Google Scholar]
- WHO. Fiftieth World Health Assembly, Geneva, 5–14 May 1997: Resolutions and Decisions; World Health Organization: Geneva, Switzerland, 1997. [Google Scholar]
- WHO. Global programme to eliminate lymphatic filariasis: Progress report for 2012. Wkly. Epidemiol. Rec. 2013, 88, 389–399. [Google Scholar]
- Zambian Ministry of Health. Zambia Neglected Tropical Diseases Master Plan 2022–2026; Ministry of Health: Lusaka, Zambia, 2023.
- Noormahomed, E.V.; Akrami, K.; Mascaró-Lazcano, C. Onchocerciasis, an undiagnosed disease in Mozambique: Identifying research opportunities. Parasites Vectors 2016, 9, 180. [Google Scholar] [CrossRef]
- Schmidt, C.A.; Cromwell, E.A.; Hill, E.; Donkers, K.M.; Schipp, M.F.; Johnson, K.B.; Pigott, D.M.; Schmidt, C.A.; Hay, S.I. The prevalence of onchocerciasis in Africa and Yemen, 2000–2018: A geospatial analysis. BMC Med. 2022, 20, 293. [Google Scholar] [CrossRef] [PubMed]
- Simonsen, P.E.; Malecela, M.; Michael, E.; Mackenzie, C.D. Lymphatic Filariasis: Research and Control in Eastern and Southern Africa; Centre for Health Research and Development: Copenhagen, Denmark, 2008. [Google Scholar]
- WHO. Global programme to eliminate lymphatic filariasis: Progress report, 2015. Wkly. Epidemiol. Rec. 2016, 91, 441–460. [Google Scholar]
- WHO. Global programme to eliminate lymphatic filariasis: Progress report, 2013. Wkly. Epidemiol. Rec. 2014, 89, 409–418. [Google Scholar]
- WHO. Global programme to eliminate lymphatic filariasis: Progress report, 2016. Wkly. Epidemiol. Rec. 2017, 92, 594–607. [Google Scholar]
- WHO. Global programme to eliminate lymphatic filariasis: Progress report, 2017. Wkly. Epidemiol. Rec. 2018, 93, 589–602. [Google Scholar]
- WHO. Global programme to eliminate lymphatic filariasis: Progress report, 2018. Wkly. Epidemiol. Rec. 2019, 94, 457–472. [Google Scholar]
- WHO. Global programme to eliminate lymphatic filariasis: Progress report, 2019. Wkly. Epidemiol. Rec. 2020, 95, 509–524. [Google Scholar]
- WHO. Global programme to eliminate lymphatic filariasis: Progress report, 2020. Wkly. Epidemiol. Rec. 2021, 96, 497–508. [Google Scholar]
- WHO. Diagnostic Test for Lymphatic Filariasis to Support Decisions for Stopping Triple-Therapy Mass Drug Administration: Target Product Profile; World Health Organization: Geneva, Switzerland, 2021. [Google Scholar]
- Atinbire, S.A.; Marfo, B.; Alomatu, B.; Ahorlu, C.; Saunderson, P.; Weiland, S. The development of a capacity-strengthening program to promote self-care practices among people with lymphatic filariasis-related lymphedema in the Upper West Region of Ghana. Infect. Dis. Poverty 2021, 10, 64. [Google Scholar] [CrossRef]
- Nsakashalo-Senkwe, M.; Mwase, E.; Chizema-Kawesha, E.; Mukonka, V.; Songolo, P.; Masaninga, F.; Rebollo, M.; Thomas, B.; Bockarie, M.; Betts, H.; et al. Significant decline in lymphatic filariasis associated with nationwide scale-up of insecticide-treated nets in Zambia. Parasite Epidemiol. Control 2017, 2, 7–14. [Google Scholar] [CrossRef]
- Zambian Ministry of Health. Zambia’s 2018 Malaria Indicator Survey. 2018. Available online: https://static1.squarespace.com/static/58d002f017bffcf99fe21889/t/5cd548ae104c7b5d9b6eb600/1557481648582/MIS2018_Fact_Sheet_20190415.pdf (accessed on 19 August 2023).
- Zambian Ministry of Health. National Malaria Elimination Strategic Plan 2017–2021; Ministry of Health: Lusaka, Zambia, 2017.
- van den Berg, H.; Kelly-Hope, L.A.; Lindsay, S.W. Malaria and lymphatic filariasis: The case for integrated vector management. Lancet Infect. Dis. 2013, 13, 89–94. [Google Scholar] [CrossRef] [PubMed]
- Muturi, E.J.; Mbogo, C.M.; Ng’ang’a, Z.W.; Kabiru, E.W.; Mwandawiro, C.; Novak, R.J.; Beier, J.C. Relationship between malaria and filariasis transmission indices in an endemic area along the Kenyan Coast. J. Vector Borne Dis. 2006, 43, 77–83. [Google Scholar] [PubMed]
- Blum, A.J.; Hotez, P.J. Global “worming”: Climate change and its projected general impact on human helminth infections. PLoS Negl. Trop. Dis. 2018, 12, e0006370. [Google Scholar] [CrossRef]
- Shirley, H.; Grifferty, G.; Yates, E.F.; Raykar, N.; Wamai, R.; McClain, C.D. The Connection between Climate Change, Surgical Care and Neglected Tropical Diseases. Ann. Glob. Health 2022, 88, 68. [Google Scholar] [CrossRef]
- Slater, H.; Michael, E. Mapping, Bayesian Geostatistical Analysis and Spatial Prediction of Lymphatic Filariasis Prevalence in Africa. PLoS ONE 2013, 8, e71574. [Google Scholar] [CrossRef] [PubMed]
- Nawrotzki, R.J.; Dewaard, J. Putting trapped populations into place: Climate change and inter-district migration flows in Zambia. Reg. Environ. Chang. 2018, 18, 533–546. [Google Scholar] [CrossRef] [PubMed]
- Simatele, D.; Simatele, M. Migration as an adaptive strategy to climate variability: A study of the Tonga-speaking people of Southern Zambia. Disasters 2015, 39, 762–781. [Google Scholar] [CrossRef]
- United Nations High Commissioner for Refugees. Global Trends—Forced Displacement in 2022; United Nations High Commissioner for Refugees: Copenhagen, Denmark, 2023. [Google Scholar]
- Abdoli, A. Helminths and COVID-19 Co-Infections: A Neglected Critical Challenge. ACS Pharmacol. Transl. Sci. 2020, 3, 1039–1041. [Google Scholar] [CrossRef]
- CDC. Guidance for Evaluation and Treatment. Centers for Disease Control. 2020. Available online: https://www.cdc.gov/parasites/lymphaticfilariasis/health_professionals/dxtx.html (accessed on 24 July 2023).
- Cheke, R.A.; Basáñez, M.-G.; Perry, M.; White, M.T.; Garms, R.; Obuobie, E.; Lamberton, P.H.L.; Young, S.; Osei-Atweneboana, M.Y.; Intsiful, J.; et al. Potential effects of warmer worms and vectors on onchocerciasis transmission in West Africa. Philos. Trans. R. Soc. B Biol. Sci. 2015, 370, 20130559. [Google Scholar] [CrossRef]
- Stone, C.M.; Lindsay, S.W.; Chitnis, N. How Effective is Integrated Vector Management against Malaria and Lymphatic Filariasis Where the Diseases Are Transmitted by the Same Vector? PLoS Negl. Trop. Dis. 2014, 8, e3393. [Google Scholar] [CrossRef]
- Adekeye, O.; Ozano, K.; Dixon, R.; Elhassan, E.O.; Lar, L.; Schmidt, E.; Isiyaku, S.; Okoko, O.; Thomson, R.; Theobald, S.; et al. Mass administration of medicines in changing contexts: Acceptability, adaptability and community directed approaches in Kaduna and Ogun States, Nigeria. PLoS Negl. Trop. Dis. 2020, 14, e0008857. [Google Scholar] [CrossRef] [PubMed]
- Nyawira, L.; Njuguna, R.G.; Tsofa, B.; Musiega, A.; Munywoki, J.; Hanson, K.; Mulwa, A.; Molyneux, S.; Maina, I.; Normand, C.; et al. Examining the influence of health sector coordination on the efficiency of county health systems in Kenya. BMC Health Serv. Res. 2023, 23, 355. [Google Scholar] [CrossRef] [PubMed]
- Fürst, T.; Salari, P.; Llamas, L.M.; Steinmann, P.; Fitzpatrick, C.; Tediosi, F. Global health policy and neglected tropical diseases: Then, now, and in the years to come. PLoS Negl. Trop. Dis. 2017, 11, e0005759. [Google Scholar] [CrossRef] [PubMed]
- Zambian Ministry of Health. National Malaria Elimination Strategic Plan 2022–2026; Ministry of Health: Lusaka, Zambia, 2022.
- Mukonka, V.M.; Chanda, E.; Haque, U.; Kamuliwo, M.; Mushinge, G.; Chileshe, J.; Chibwe, K.A.; Norris, D.E.; Mulenga, M.; Chaponda, M.; et al. High burden of malaria following scale-up of control interventions in Nchelenge District, Luapula Province, Zambia. Malar. J. 2014, 13, 153. [Google Scholar] [CrossRef] [PubMed]
- Fuller, B.B.; Harris, V.; Parker, C.; Martinez, A.; Toubali, E.; Ebene, B.C.; Asemanyi-Mensah, K.; Dembele, M.; Salissou, A.B.; Kabré, C.; et al. Contextual determinants of mass drug administration performance: Modelling fourteen years of lymphatic filariasis treatments in West Africa. PLoS Negl. Trop. Dis. 2023, 17, e0011146. [Google Scholar] [CrossRef]
- Toor, J.; Adams, E.R.; Aliee, M.; Amoah, B.; Anderson, R.M.; Ayabina, D.; Bailey, R.; Basáñez, M.-G.; Blok, D.J.; Blumberg, S.; et al. Predicted Impact of COVID-19 on Neglected Tropical Disease Programs and the Opportunity for Innovation. Clin. Infect. Dis. 2021, 72, 1463–1466. [Google Scholar] [CrossRef]
- Prada, J.M.; Stolk, W.A.; Davis, E.L.; Touloupou, P.; Sharma, S.; Muñoz, J.; Caja Rivera, R.M.; Reimer, L.J.; Michael, E.; De Vlas, S.J.; et al. Delays in lymphatic filariasis elimination programmes due to COVID-19, and possible mitigation strategies. Trans. R. Soc. Trop. Med. Hyg. 2021, 115, 261–268. [Google Scholar] [CrossRef]
- Mudenda, S.; Chileshe, M.; Mukosha, M.; Hikaambo, C.N.; Banda, M.; Kampamba, M.; Mwila, K.; Banda, D.C.; Mufwambi, W.; Daka, V. Zambia’s Response to the COVID-19 Pandemic: Exploring Lessons, Challenges and Implications for Future Policies and Strategies. Pharmacol. Pharm. 2022, 13, 11–33. [Google Scholar] [CrossRef]
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Chimfwembe, K.; Shirley, H.; Baker, N.; Wamai, R. Zambia: A Narrative Review of Success and Challenges in Lymphatic Filariasis Elimination. Trop. Med. Infect. Dis. 2024, 9, 21. https://doi.org/10.3390/tropicalmed9010021
Chimfwembe K, Shirley H, Baker N, Wamai R. Zambia: A Narrative Review of Success and Challenges in Lymphatic Filariasis Elimination. Tropical Medicine and Infectious Disease. 2024; 9(1):21. https://doi.org/10.3390/tropicalmed9010021
Chicago/Turabian StyleChimfwembe, Kingford, Hugh Shirley, Natalie Baker, and Richard Wamai. 2024. "Zambia: A Narrative Review of Success and Challenges in Lymphatic Filariasis Elimination" Tropical Medicine and Infectious Disease 9, no. 1: 21. https://doi.org/10.3390/tropicalmed9010021