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Schistosome Vaccines for Domestic Animals

Molecular Parasitology Laboratory, QIMR Berghofer Medical Research Institute, Brisbane, QLD 4006, Australia
Author to whom correspondence should be addressed.
Trop. Med. Infect. Dis. 2018, 3(2), 68;
Received: 18 May 2018 / Revised: 5 June 2018 / Accepted: 14 June 2018 / Published: 19 June 2018
(This article belongs to the Special Issue Prospects for Schistosomiasis Elimination)
Schistosomiasis is recognized as a tropical disease of considerable public health importance, but domestic livestock infections due to Schistosoma japonicum, S. bovis, S. mattheei and S. curassoni are often overlooked causes of significant animal morbidity and mortality in Asia and Africa. In addition, whereas schistosomiasis japonica is recognized as an important zoonosis in China and the Philippines, reports of viable schistosome hybrids between animal livestock species and S. haematobium point to an underappreciated zoonotic component of transmission in Africa as well. Anti-schistosome vaccines for animal use have long been advocated as part of the solution to schistosomiasis control, benefitting humans and animals and improving the local economy, features aligning with the One Health concept synergizing human and animal health. We review the history of animal vaccines for schistosomiasis from the early days of irradiated larvae and then consider the recombinant DNA technology revolution and its impact in developing schistosome vaccines that followed. We evaluate the major candidates tested in livestock, including the glutathione S-transferases, paramyosin and triose-phosphate isomerase, and summarize some of the future challenges that need to be overcome to design and deliver effective anti-schistosome vaccines that will complement current control options to achieve and sustain future elimination goals. View Full-Text
Keywords: schistosomiasis; Schistosoma; vaccine; zoonosis; Asia; Africa; domestic animals; buffalo; cattle; sheep; goats schistosomiasis; Schistosoma; vaccine; zoonosis; Asia; Africa; domestic animals; buffalo; cattle; sheep; goats
MDPI and ACS Style

You, H.; Cai, P.; Tebeje, B.M.; Li, Y.; McManus, D.P. Schistosome Vaccines for Domestic Animals. Trop. Med. Infect. Dis. 2018, 3, 68.

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