Schistosome Vaccines for Domestic Animals
Abstract
1. Introduction
2. The Early Days—Irradiated Larval Vaccines
3. The Impact of Recombinant DNA Technology on the Development of Animal Vaccines for Schistosomiasis
3.1. The Glutathione S-Transferases
3.2. Paramyosin
3.3. Triose-Phosphate Isomerase (TPI)
4. Challenges and Opportunities for the Future
Author Contributions
Funding
Acknowledgments
Conflicts of Interest
References
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Host | Antigen | Method of Immunization Regimen | Vaccine Efficacy | Ref | ||
---|---|---|---|---|---|---|
Worm Burden Reduction % | Liver Egg Burden Reduction % | Fecal Egg Reduction % | ||||
Pig | UV-attenuated cercariae | Single/three immunizations | 59–78 | 89 | 86–99.7 | [31] |
Irradiated cercariae | >95 | >95 | >95 | [28] | ||
SjC23-pcDNA3.1 DNA | Conjunction with/without IL-12 | 29–58 | 48–56 | [56] | ||
SjTPI-pcDNA3.1 DNA | Conjunction with/without IL-12 | 46–48 | 49–66 | [57] | ||
Paramyosin | Conjugated with alum or TiterMax | 32–34 | [27] | |||
Water buffalo | Paramyosin | Montanide ISA 206 | 52–58 | [58] | ||
SjCTPI DNA | Fused to bovine heat shock protein 70 | 41–51 | 42–62 | 33–52 (miracidial hatching) | [10] | |
SjC23DNA | (Hsp70) and boosted with a plasmid DNA encoding IL-12 | 45–51 | 43–54 | 47–52 (miracidial hatching) | ||
Sjc26GST (field study) | Twenty months after vaccination, the infection rate in buffaloes was reduced by 60–68% | [53] | ||||
Sjc26GST | 22 | 50 | 50 | [52] | ||
Sj28GST (field study) | Injected with Freund’s adjuvants | 37 | 33 | 62 (miracidial hatching) | [46] | |
Cryopreserved-irradiated and freeze-thaw schistosomula | Single/twice intradermal vaccination | 62–65 | [22] | |||
Cercariae UV irradiated | Six immunizations | 89 | [24] | |||
Goat | Sj31 and Sj32 | DNA priming-protein boosting | 21–32 | 47–52 | 48–54 (miracidial hatching) | [59] |
Cattle | Sj26GST | 30 | 60 | [54] | ||
Sj28GST-DNA | Three immunizations | 44 | 19 | 77 | [47] | |
Sj23-DNA | 33 | 34 | 66 | |||
Sj28GST + Sj23-DNA | 38 | 48 | 68 | |||
Sheep | Sj26GST | Injected with Freund’s adjuvants | 54–62 | 42–55 | 11–38 | [45,46] |
Sj28GST | 61–69 | 59–69 | 43–60 | |||
Sj23 | 58–66 | 56–66 | 40–58 | |||
Native Paramyosin | 68 | 43 | ||||
Paramyosin | 56 | 16 |
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You, H.; Cai, P.; Tebeje, B.M.; Li, Y.; McManus, D.P. Schistosome Vaccines for Domestic Animals. Trop. Med. Infect. Dis. 2018, 3, 68. https://doi.org/10.3390/tropicalmed3020068
You H, Cai P, Tebeje BM, Li Y, McManus DP. Schistosome Vaccines for Domestic Animals. Tropical Medicine and Infectious Disease. 2018; 3(2):68. https://doi.org/10.3390/tropicalmed3020068
Chicago/Turabian StyleYou, Hong, Pengfei Cai, Biniam Mathewos Tebeje, Yuesheng Li, and Donald P. McManus. 2018. "Schistosome Vaccines for Domestic Animals" Tropical Medicine and Infectious Disease 3, no. 2: 68. https://doi.org/10.3390/tropicalmed3020068
APA StyleYou, H., Cai, P., Tebeje, B. M., Li, Y., & McManus, D. P. (2018). Schistosome Vaccines for Domestic Animals. Tropical Medicine and Infectious Disease, 3(2), 68. https://doi.org/10.3390/tropicalmed3020068