Melioidosis: An Australian Perspective
Abstract
:1. History
2. Melioidosis Cases and the Presence of B. pseudomallei
3. Surveillance Systems and Reporting
4. Diagnosis
5. Treatment
6. Awareness and Prevention of Melioidosis
7. Major Achievements
8. Current and Future Challenges
Acknowledgments
Author Contributions
Conflicts of Interest
References
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Phase | Antibiotic | Adult Dose | Child Dose |
---|---|---|---|
Intensive | Meropenem | 1 g intravenously 8-hourly 2 g intravenously 8-hourly 1 | 25 mg/kg up to 1 g intravenously 8-hourly 50 mg/kg up to 2 g intravenously 8-hourly 1 |
Intensive | Ceftazidime | 2 g intravenously 6-hourly | 50 mg/kg up to 2 g intravenously 6-hourly |
Intensive and eradication | Trimethoprim-sulfamethoxazole | ≥60 kg: 320 + 1600 mg orally 12-hourly 40–60 kg: 240 + 1200 mg orally 12-hourly | 6 + 30 mg/kg up to 240 + 1200 mg orally 12-hourly |
Eradication | Amoxicillin-clavulanate | 20/5 mg/kg orally 8-hourly | 20/5 mg/kg orally 8-hourly |
Eradication | Doxycycline | 100 mg orally 12-hourly | Not recommended |
Site of Infection | Minimum Intensive Phase Duration (Weeks) | Eradication Phase Duration (Months) |
---|---|---|
Cutaneous infection only | 2 | 3 |
Bacteraemia without focus | 2 | 3 |
Pneumonia without lymphadenopathy or ICU admission | 2 | 3 |
Pneumonia with lymphadenopathy 1 or ICU admission | 4 | 3 |
Deep seated collection 2 | 4 3 | 3 |
Septic arthritis | 4 3 | 3 |
Osteomyelitis | 6 | 6 |
Central nervous system infection | 8 | 6 |
Mycotic aneurysm or other arterial infection | 8 | 6 |
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Smith, S.; Hanson, J.; Currie, B.J. Melioidosis: An Australian Perspective. Trop. Med. Infect. Dis. 2018, 3, 27. https://doi.org/10.3390/tropicalmed3010027
Smith S, Hanson J, Currie BJ. Melioidosis: An Australian Perspective. Tropical Medicine and Infectious Disease. 2018; 3(1):27. https://doi.org/10.3390/tropicalmed3010027
Chicago/Turabian StyleSmith, Simon, Josh Hanson, and Bart J. Currie. 2018. "Melioidosis: An Australian Perspective" Tropical Medicine and Infectious Disease 3, no. 1: 27. https://doi.org/10.3390/tropicalmed3010027