Next Article in Journal
Confronting the Emerging Threat to Public Health in Northern Australia of Neglected Indigenous Arboviruses
Previous Article in Journal
Infection of Rodents by Orientia tsutsugamushi, the Agent of Scrub Typhus in Relation to Land Use in Thailand
Review

The Impact of Antimalarial Use on the Emergence and Transmission of Plasmodium falciparum Resistance: A Scoping Review of Mathematical Models

1
School of Nursing and Midwifery, Division of Health Sciences, University of South Australia, Adelaide, SA 5000, Australia
2
Library, University of South Australia, Adelaide, SA 5000, Australia
3
School of Mathematical Sciences, The University of Adelaide, Adelaide, SA 5005, Australia
4
Sansom Institute for Research Health, University of South Australia, Adelaide, SA 5000, Australia
5
Australian Institute of Tropical Health and Medicine, James Cook University, Smithfield, QLD 4878, Australia
*
Author to whom correspondence should be addressed.
Trop. Med. Infect. Dis. 2017, 2(4), 54; https://doi.org/10.3390/tropicalmed2040054
Received: 8 September 2017 / Revised: 4 October 2017 / Accepted: 6 October 2017 / Published: 15 October 2017
The emergence and transmission of resistance to antimalarial treatments continue to hamper malaria elimination efforts. A scoping review was undertaken regarding the impact of antimalarial treatment in the human population on the emergence and transmission of Plasmodium falciparum resistance, to (i) describe the use of mathematical models used to explore this relationship; (ii) discuss model findings; and (iii) identify factors influencing the emergence and transmission of resistance. Search strategies were developed and deployed in six major databases. Thirty-seven articles met the eligibility criteria and were included in the review: nine articles modeled the emergence of resistance, 19 modeled the transmission of resistance, and nine modeled both the emergence and transmission. The proportion of antimalarial use within the population and the presence of residual drug concentrations were identified to be the main predictors of the emergence and transmission of resistance. Influencing factors pertaining to the human, parasite and mosquito populations are discussed. To ensure the prolonged therapeutic usefulness of antimalarial treatments, the effect of antimalarial drug use on the emergence and transmission of resistance must be understood, and mathematical models are a useful tool for exploring these dynamics. View Full-Text
Keywords: scoping review; malaria; Plasmodium falciparum; mathematical model; antimalarial resistance; antimalarial treatment; subtherapeutic; drug quality scoping review; malaria; Plasmodium falciparum; mathematical model; antimalarial resistance; antimalarial treatment; subtherapeutic; drug quality
Show Figures

Figure 1

MDPI and ACS Style

Brock, A.R.; Gibbs, C.A.; Ross, J.V.; Esterman, A. The Impact of Antimalarial Use on the Emergence and Transmission of Plasmodium falciparum Resistance: A Scoping Review of Mathematical Models. Trop. Med. Infect. Dis. 2017, 2, 54. https://doi.org/10.3390/tropicalmed2040054

AMA Style

Brock AR, Gibbs CA, Ross JV, Esterman A. The Impact of Antimalarial Use on the Emergence and Transmission of Plasmodium falciparum Resistance: A Scoping Review of Mathematical Models. Tropical Medicine and Infectious Disease. 2017; 2(4):54. https://doi.org/10.3390/tropicalmed2040054

Chicago/Turabian Style

Brock, Aleisha R., Carole A. Gibbs, Joshua V. Ross, and Adrian Esterman. 2017. "The Impact of Antimalarial Use on the Emergence and Transmission of Plasmodium falciparum Resistance: A Scoping Review of Mathematical Models" Tropical Medicine and Infectious Disease 2, no. 4: 54. https://doi.org/10.3390/tropicalmed2040054

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop