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Targeting the P2X7 Receptor in Age-Related Macular Degeneration
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The Role of the P2X7 Receptor in Ocular Stresses: A Potential Therapeutic Target

by Mélody Dutot 1,2,†, Elodie Olivier 1,†, Anaïs Wakx 1 and Patrice Rat 1,*
1
UMR 8638 CNRS COMETE, Université Paris Descartes, Sorbonne Paris Cité, Faculté de Pharmacie, 4 Avenue de l’Observatoire, 75006 Paris, France
2
Recherche et Développement, Laboratoire d’Evaluation Physiologique, Yslab, 2 rue Félix Le Dantec, 29000 Quimper, France
*
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Academic Editors: Tetsuya Sugiyama and Andrew Parker
Vision 2017, 1(2), 14; https://doi.org/10.3390/vision1020014
Received: 28 February 2017 / Revised: 10 April 2017 / Accepted: 14 May 2017 / Published: 17 May 2017
(This article belongs to the Special Issue Purinergic Receptors in the Eye)
The P2X7 receptor is expressed in both anterior and posterior segments of the eyeball. In the ocular surface, the P2X7 receptor is activated in case of external aggressions: preservatives and surfactants induce the activation of P2X7 receptors, leading to either apoptosis, inflammation, or cell proliferation. In the retina, the key endogenous actors of age-related macular degeneration, diabetic retinopathy, and glaucoma act through P2X7 receptors’ activation and/or upregulation of P2X7 receptors’ expression. Different therapeutic strategies aimed at the P2X7 receptor exist. P2X7 receptor antagonists, such as divalent cations and Brilliant Blue G (BBG) could be used to target either the ocular surface or the retina, as long as polyunsaturated fatty acids may exert their effects through the disruption of plasma membrane lipid rafts or saffron that reduces the response evoked by P2X7 receptor stimulation. Treatments against P2X7 receptor activation are proposed by using either eye drops or food supplements. View Full-Text
Keywords: ocular; stress; P2X7 receptor; modulation; therapeutic target ocular; stress; P2X7 receptor; modulation; therapeutic target
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MDPI and ACS Style

Dutot, M.; Olivier, E.; Wakx, A.; Rat, P. The Role of the P2X7 Receptor in Ocular Stresses: A Potential Therapeutic Target. Vision 2017, 1, 14.

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