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Volume 10
Issue 4
10.3390/jfmk10040454
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Review

Knee Health Is a Major Determinant of Mobility Across the Healthspan

by
Brandon Marshall Peoples
1,
Kenneth D. Harrison
1,
Michael A. Samaan
2,
Christopher B. Mobley
1,
David T. Redden
3 and
Jaimie A. Roper
1,*
1
School of Kinesiology, Auburn University, Auburn, AL 36849, USA
2
Department of Kinesiology & Health Promotion, University of Kentucky, Lexington, KY 40506, USA
3
Edward Via College of Osteopathic Medicine, Auburn University, Auburn, AL 36849, USA
*
Author to whom correspondence should be addressed.
J. Funct. Morphol. Kinesiol. 2025, 10(4), 454; https://doi.org/10.3390/jfmk10040454 (registering DOI)
Submission received: 25 September 2025 / Revised: 14 November 2025 / Accepted: 17 November 2025 / Published: 20 November 2025
(This article belongs to the Collection Feature Papers in Journal of Functional Morphology and Kinesiology)
Review Reports Versions Notes

Abstract

Knee health constitutes a pivotal determinant of locomotor function and overall mobility throughout the healthspan. Impairments in knee function lead to a series of biomechanical and physiological alterations that pose substantial public health challenges and economic burdens worldwide. This review synthesizes evidence that delineates the complex and multifaceted relationship between knee health and mobility, emphasizing the interplay across various domains in adult populations. Knee health is conceptualized as a dynamic, interconnected system whereby structural integrity, neuromuscular mechanisms, biomechanical adaptations, and functional mobility are intricately interrelated through cascades of mechanistic processes operating across different temporal stages. A comprehensive understanding of these interrelationships is necessary for developing precise and targeted interventions that aim to preserve mobility and functional independence throughout the healthspan.
Keywords: ACL; mobility; gait biomechanics; knee injury; osteoarthritis ACL; mobility; gait biomechanics; knee injury; osteoarthritis

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MDPI and ACS Style

Peoples, B.M.; Harrison, K.D.; Samaan, M.A.; Mobley, C.B.; Redden, D.T.; Roper, J.A. Knee Health Is a Major Determinant of Mobility Across the Healthspan. J. Funct. Morphol. Kinesiol. 2025, 10, 454. https://doi.org/10.3390/jfmk10040454

AMA Style

Peoples BM, Harrison KD, Samaan MA, Mobley CB, Redden DT, Roper JA. Knee Health Is a Major Determinant of Mobility Across the Healthspan. Journal of Functional Morphology and Kinesiology. 2025; 10(4):454. https://doi.org/10.3390/jfmk10040454

Chicago/Turabian Style

Peoples, Brandon Marshall, Kenneth D. Harrison, Michael A. Samaan, Christopher B. Mobley, David T. Redden, and Jaimie A. Roper. 2025. "Knee Health Is a Major Determinant of Mobility Across the Healthspan" Journal of Functional Morphology and Kinesiology 10, no. 4: 454. https://doi.org/10.3390/jfmk10040454

APA Style

Peoples, B. M., Harrison, K. D., Samaan, M. A., Mobley, C. B., Redden, D. T., & Roper, J. A. (2025). Knee Health Is a Major Determinant of Mobility Across the Healthspan. Journal of Functional Morphology and Kinesiology, 10(4), 454. https://doi.org/10.3390/jfmk10040454

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