Sex, Age, and Risk Group Variations among Individuals Infected with HIV, HTLV-1, and HTLV-2: Review of Data Records (1983–2017) from a Public Health Laboratory in São Paulo, Brazil
Abstract
:1. Introduction
2. Materials and Methods
2.1. Study Design and Works Selection Criteria
2.2. Data Presentation and Statistical Analysis
2.3. Ethics Approval
3. Results and Commentaries
3.1. Cellular Immune Profile in AIDS (1983–1985)
3.2. HIV Diagnosis in Children (1989–1993)
3.3. HIV/HTLV Co-Infections in Patients Attended by One Hospital of São Paulo (1991–1994)
3.4. HIV/HTLV Co-Infections in Londrina, Paraná (2001–2002)
3.5. HIV/HTLV Co-Infections in Patients of Several CRTAs and Out-Patient Clinics of São Paulo (1999–2006)
3.6. HIV/HTLV Co-Infections in Patients of the Pioneer CRTA-SP (2014–2015)
3.7. HIV and HIV/HTLV Co-Infection in Patients of Several CRTAs of São Paulo (2010–2016)
3.8. HIV/HTLV Co-Infections in Recent CRTA Settings in São Paulo (2012–2015)
3.9. Variations in HIV/HTLV Co-Infection Prevalence Rates Regarding the Years of Sample Collection (1991–2015)
4. Discussion
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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Groups | ||||
---|---|---|---|---|
CONTROL (n = 11) | RISK (n = 27) | LAS/ARC (n = 37) | AIDS (n = 47) | |
Age (years) | 30.4 | 30.7 | 31.9 | 30.8 |
Leucocytes/mm3 | 5263.6 | 5955.6 | 5689.2 | 4763.8 * |
Lymphocytes/mm3 | 1967.6 | 2316.7 | 2264.2 | 1218.2 * |
T lymphocyte (%) | 64.0 | 64.8 | 62.2 | 52.1 * |
T lymphocytes/mm3 | 1247 | 1509.8 | 1403.9 | 662.3 * |
B lymphocytes (%) | 18.2 | 16.6 | 15.0 | 18.6 |
B lymphocytes/mm3 | 397.3 | 362.7 | 307.6 | 214.4 * |
T4 (%) | 44.4 | 37.8 | 26.3 | 13.5 * |
T4/mm3 | 863 | 833.9 | 591.4 | 191.2 * |
T8 (%) | 21.6 | 26.6 | 37.3 * | 39.0 * |
T8/mm3 | 451.9 | 620.2 | 797.6 * | 550.7 |
T4/T8 | 2.3 | 1.6 | 0.74 * | 0.53 * |
PHA 20 µg/mL | 255,979.7 | 233,381.8 | 175,852.9 | 118,450.1 * |
Con-A 20 µg/mL | 172,269.5 | 136,493.3 | 111,128.2 | 54,795.5 * |
PWM 20 µg/mL | 75,942.8 | 71,469.8 | 27,760.5 | 17,930.1 * |
PPD 10 µg/mL | 59,989.1 | 16,696.0 | 15,505.3 * | 7098.8 * |
Year of Collection | Local/ Group | Number of Cases | Mean Age (Years) | Sex (Number) | HTLV-1/-2 (%) | HTLV-1 (%) | HTLV-2 (%) | Ref. |
---|---|---|---|---|---|---|---|---|
1991–1992 | IIER, SP | 471 | M (406) F (65) | 62 (13.2) | 37 (7.9) | 25 (5.3) | [30] | |
IDU | 216 | 29 | M (155) F (61) | 57 (26.4) | 33 (15.3) | 24 (11.1) | ||
Homo/Bis | 229 | 34 | M (229) | 3 (1.3) | 2 (0.9) | 1 (0.4) | ||
Others a | 26 | 30 | M (22) F (4) | 2 (7.7) | 2 (7.7) | |||
1994 | IIER, SP | 553 | 32 | M (358) F (195) | 56 (10.1) | 22 (4.0) | 34 (6.1) | [31] |
IDU | 89 | 29 | M (65) F (24) | 25 (28.0) | 10 (11.2) | 15 (16.8) | ||
Hetero | 236 | 33 | M (96) F (140) | 21 (8.9) | 8 (3.4) | 13 (5.5) | ||
Homo/Bis | 139 | 33 | M (139) | 5 (3.6) | 2 (1.4) | 3 (2.2) | ||
Others/Unk b | 89 | 32 | M (58) F (31) | 5 (5.6) | 2 (2.2) | 3 (3.4) | ||
2001–2002 | CRTA-PR | 758 | 36 | M (424) F (334) | 43 (5.7) | 6 (0.8) | 37 (4.9) | [32,33] |
Sexual | 633 | 16 (2.5) | 2 (0.3) | 14 (2.2) | ||||
IDU | 57 | 17 (29.8) | 2 (3.5) | 15 (26.3) | ||||
Sexual + IDU | 33 | 7 (21.2) | 1 (3.0) | 6 (18.2) | ||||
Other c | 35 | 3 (8.6) | 1 (2.9) | 2 (5.7) | ||||
1999–2006 | CRTAs, SP | 1393 | M (982) F (411) | 81 (5.8) | 46 (3.3) | 35 (2.5) | [34] | |
Clinics, SP | 919 | M (538) F (381) | 121 (13.2) | 88 (9.6) | 33 (3.6) | |||
2014–2015 | CRTA-SP | 1608 | 44 | M (1237) F (371) | 50 (3.1) | 26 (1.6) | 22 (1.4) | [35] |
2012–2015 | CRTAs, SP | 1383 | 36 | M (930) F (453) | 58 (4.2) | 29 (2.1) | 24 (1.7) | [36,37] |
Location | Year of Collection | Number of Samples | HIV/HTLV (%) | HIV/HTLV-1 (%) | HIV/HTLV-2 (%) | Risk Factors/ Associations | Ref. |
---|---|---|---|---|---|---|---|
North | |||||||
Belém, Pará | 1994–1996 | 149 | 7.4 | 2.7 | 4.7 | Homosexual/bisexual men, IDU | [48] |
Belém, Pará | 2005 | 117 | 5.1 | 1.7 | 3.4 | Unknown | [49] |
Belém, Pará | 2016–2017 | 368 | 1.4 | 1.4 | 0 | Female, sexual contact, sporadic condom use | [50] |
Northeast | |||||||
Salvador, Bahia | 1994–1995 | 123 | 20.3 | 17.1 | 3.2 | IDU | [51] |
State of Bahia | 2004–2013 | 1733 | 2.4 | 2.1 | 0.3 | Female, sexual contact, from Salvador | [52] |
State of Piauí | 2012 | 805 | 1.6 | 1.1 | 0.5 | Blood transfusion, surgeries, >40 years | [53] |
João Pessoa, Paraíba | 2015 | 401 | 1.5 | 1.5 | 0 | None | [54] |
Southeast | |||||||
Santos, São Paulo | 1997–1998 | 499 | 13.4 | 6.0 | 7.4 | Male, IDU, HCV, no condom use | [55] |
Ribeirão Preto and São Paulo, São Paulo | 2001 | 319 | 4.7 | 0.6 | 4.1 | IDU, HCV | [56] |
South | |||||||
Porto Alegre, Rio Grande do Sul | 1996 | 2985 | 2.4 | 1.4 | 1.0 | IDU, >30 years | [57] |
Canoas, Rio Grande do Sul | 2008–2009 | 580 | 2.9 | 1.9 | 1.0 | Blood transfusion, tattoo, alcohol abuse | [58] |
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Caterino-de-Araujo, A. Sex, Age, and Risk Group Variations among Individuals Infected with HIV, HTLV-1, and HTLV-2: Review of Data Records (1983–2017) from a Public Health Laboratory in São Paulo, Brazil. Sexes 2023, 4, 638-655. https://doi.org/10.3390/sexes4040041
Caterino-de-Araujo A. Sex, Age, and Risk Group Variations among Individuals Infected with HIV, HTLV-1, and HTLV-2: Review of Data Records (1983–2017) from a Public Health Laboratory in São Paulo, Brazil. Sexes. 2023; 4(4):638-655. https://doi.org/10.3390/sexes4040041
Chicago/Turabian StyleCaterino-de-Araujo, Adele. 2023. "Sex, Age, and Risk Group Variations among Individuals Infected with HIV, HTLV-1, and HTLV-2: Review of Data Records (1983–2017) from a Public Health Laboratory in São Paulo, Brazil" Sexes 4, no. 4: 638-655. https://doi.org/10.3390/sexes4040041