Next Article in Journal
A Rare Case of Malonic Aciduria Diagnosed by Newborn Screening in Qatar
Previous Article in Journal
Newborn Screening for Krabbe Disease and Other Lysosomal Storage Disorders: Broad Lessons Learned
Case Report

The Risk from Anti-Thyroid Hormone Antibody Interference in Neonatal Congenital Hypothyroidism Screening

Clinical Chemistry Laboratory, Department of Pathology, Mater Dei Hospital, Malta
*
Author to whom correspondence should be addressed.
Academic Editor: Peter C.J.I. Schielen
Int. J. Neonatal Screen. 2017, 3(1), 4; https://doi.org/10.3390/ijns3010004
Received: 17 November 2016 / Revised: 20 February 2017 / Accepted: 1 March 2017 / Published: 2 March 2017
Neonatal congenital hypothyroidism screening is considered to be one of the most effective newborn screening strategies. Neonatal screening for congenital hypothyroidism involves the analysis of thyroid hormone and thyrotropin levels using an immunoassay based technique. Immunoassays are also prone to analytical problems such as assay interference. Immunoassays used for thyroid hormone measurement are known to be affected from anti-thyroid hormone antibody interference. This is the first reported case of interference presumably caused by anti-thyroid hormone antibodies transferred from mother to child during pregnancy, affecting the measurement of free-thyroxine in a cord-blood sample. We report a case of a full-term newborn with presumed anti-thyroid hormone antibody interference present in both cord blood and subsequent venous blood samples. In the context of a newborn screening programme based solely on thyroxine measurement, this is an important finding, since it has the potential to cause false negative screening results. View Full-Text
Keywords: neonatal hypothyroidism screening; anti-thyroid hormone antibody; interference; cord-blood neonatal hypothyroidism screening; anti-thyroid hormone antibody; interference; cord-blood
MDPI and ACS Style

Brincat, I.; Buhagiar, G. The Risk from Anti-Thyroid Hormone Antibody Interference in Neonatal Congenital Hypothyroidism Screening. Int. J. Neonatal Screen. 2017, 3, 4. https://doi.org/10.3390/ijns3010004

AMA Style

Brincat I, Buhagiar G. The Risk from Anti-Thyroid Hormone Antibody Interference in Neonatal Congenital Hypothyroidism Screening. International Journal of Neonatal Screening. 2017; 3(1):4. https://doi.org/10.3390/ijns3010004

Chicago/Turabian Style

Brincat, Ian, and Gerald Buhagiar. 2017. "The Risk from Anti-Thyroid Hormone Antibody Interference in Neonatal Congenital Hypothyroidism Screening" International Journal of Neonatal Screening 3, no. 1: 4. https://doi.org/10.3390/ijns3010004

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop