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Article

Mapping Alveolar Oxygen Partial Pressure in COPD Using Hyperpolarized Helium-3: The Multi-Ethnic Study of Atherosclerosis (MESA) COPD Study

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Department of Chemical Engineering, Columbia University, New York, NY 10027, USA
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Division of General Medicine, Columbia University Irving Medial Center, New York, NY 10032, USA
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Department of Biomedical Engineering, Columbia University, New York, NY 10027, USA
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Neurological Institute, Radiology, Columbia University, New York, NY 10032, USA
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Department of Internal Medicine, University of Iowa, Iowa City, IA 52242, USA
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Mailman School of Public Health, Columbia University, New York, NY 10032, USA
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Department of Radiology, Weill Cornell Medicine, New York, NY 10065, USA
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Department of Medicine, McGill University, Montreal, QC H3G 2M1, Canada
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Department of Infection, Immunity and Cardiovascular Disease, University of Sheffield, Sheffield S10 2TN, UK
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Division of Pediatric Gastroenterology, Hepatology and Nutrition, Department of Pediatrics, Columbia University Irving Medical Center, New York, NY 10032, USA
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Institute of Human Nutrition, College of Physicians & Surgeons, Columbia University Irving Medical Center, New York, NY 10032, USA
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Columbia Magnetic Resonance Research Center (CMRRC), Columbia University, New York, NY 10027, USA
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Department of Physics, Columbia University, New York, NY 10027, USA
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Authors to whom correspondence should be addressed.
Tomography 2022, 8(5), 2268-2284; https://doi.org/10.3390/tomography8050190
Received: 3 August 2022 / Revised: 5 September 2022 / Accepted: 5 September 2022 / Published: 13 September 2022
Chronic obstructive pulmonary disease (COPD) and emphysema are characterized by functional and structural damage which increases the spaces for gaseous diffusion and impairs oxygen exchange. Here we explore the potential for hyperpolarized (HP) 3He MRI to characterize lung structure and function in a large-scale population-based study. Participants (n = 54) from the Multi-Ethnic Study of Atherosclerosis (MESA) COPD Study, a nested case-control study of COPD among participants with 10+ packyears underwent HP 3He MRI measuring pAO2, apparent diffusion coefficient (ADC), and ventilation. HP MRI measures were compared to full-lung CT and pulmonary function testing. High ADC values (>0.4 cm2/s) correlated with emphysema and heterogeneity in pAO2 measurements. Strong correlations were found between the heterogeneity of global pAO2 as summarized by its standard deviation (SD) (p < 0.0002) and non-physiologic pAO2 values (p < 0.0001) with percent emphysema on CT. A regional study revealed a strong association between pAO2 SD and visual emphysema severity (p < 0.003) and an association with the paraseptal emphysema subtype (p < 0.04) after adjustment for demographics and smoking status. HP noble gas pAO2 heterogeneity and the fraction of non-physiological pAO2 results increase in mild to moderate COPD. Measurements of pAO2 are sensitive to regional emphysematous damage detected by CT and may be used to probe pulmonary emphysema subtypes. HP noble gas lung MRI provides non-invasive information about COPD severity and lung function without ionizing radiation. View Full-Text
Keywords: quantitative MRI; COPD; average diffusion coefficient; partial pressure of oxygen; hyper polarized gas MRI quantitative MRI; COPD; average diffusion coefficient; partial pressure of oxygen; hyper polarized gas MRI
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MDPI and ACS Style

Taskiran, N.P.; Hiura, G.T.; Zhang, X.; Barr, R.G.; Dashnaw, S.M.; Hoffman, E.A.; Malinsky, D.; Oelsner, E.C.; Prince, M.R.; Smith, B.M.; Sun, Y.; Sun, Y.; Wild, J.M.; Shen, W.; Hughes, E.W. Mapping Alveolar Oxygen Partial Pressure in COPD Using Hyperpolarized Helium-3: The Multi-Ethnic Study of Atherosclerosis (MESA) COPD Study. Tomography 2022, 8, 2268-2284. https://doi.org/10.3390/tomography8050190

AMA Style

Taskiran NP, Hiura GT, Zhang X, Barr RG, Dashnaw SM, Hoffman EA, Malinsky D, Oelsner EC, Prince MR, Smith BM, Sun Y, Sun Y, Wild JM, Shen W, Hughes EW. Mapping Alveolar Oxygen Partial Pressure in COPD Using Hyperpolarized Helium-3: The Multi-Ethnic Study of Atherosclerosis (MESA) COPD Study. Tomography. 2022; 8(5):2268-2284. https://doi.org/10.3390/tomography8050190

Chicago/Turabian Style

Taskiran, Naz P., Grant T. Hiura, Xuzhe Zhang, R. Graham Barr, Stephen M. Dashnaw, Eric A. Hoffman, Daniel Malinsky, Elizabeth C. Oelsner, Martin R. Prince, Benjamin M. Smith, Yanping Sun, Yifei Sun, Jim M. Wild, Wei Shen, and Emlyn W. Hughes. 2022. "Mapping Alveolar Oxygen Partial Pressure in COPD Using Hyperpolarized Helium-3: The Multi-Ethnic Study of Atherosclerosis (MESA) COPD Study" Tomography 8, no. 5: 2268-2284. https://doi.org/10.3390/tomography8050190

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