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Assessment of Correlation between Dual-Energy Ct (De-Ct)-Derived Iodine Concentration and Local Flourodeoxyglucose (Fdg) Uptake in Patients with Primary Non-Small-Cell Lung Cancer

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Department of Radiology, Aarhus University Hospital, 8200 Aarhus, Denmark
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Department of Radiology, Copenhagen University Hospital, 2100 Copenhagen, Denmark
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Department of Clinical Engineering, Aarhus University Hospital, 8200 Aarhus, Denmark
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Clinical Science CT, Philips Healthcare, Veenpluis 4-6, 5684 PC Best, The Netherlands
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Department of Nuclear Medicine and PET, Aarhus University Hospital, 8200 Aarhus, Denmark
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Department of Clinical Medicine, Aarhus University, 8200 Aarhus, Denmark
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Danish Center for Particle Therapy, Aarhus University Hospital, 8200 Aarhus, Denmark
*
Authors to whom correspondence should be addressed.
Academic Editors: Mami Iima and Emilio Quaia
Tomography 2022, 8(4), 1770-1780; https://doi.org/10.3390/tomography8040149
Received: 19 May 2022 / Revised: 30 June 2022 / Accepted: 6 July 2022 / Published: 8 July 2022
(1) The current literature contains several studies investigating the correlation between dual-energy-derived iodine concentration (IC) and positron emission tomography (PET)-derived Flourodeoxyglucose (18F-FDG) uptake in patients with non-small-cell lung cancer (NSCLC). In previously published studies, either the entire tumor volume or a region of interest containing the maximum IC or 18F-FDG was assessed. However, the results have been inconsistent. The objective of this study was to correlate IC with FDG both within the entire volume and regional sub-volumes of primary tumors in patients with NSCLC. (2) In this retrospective study, a total of 22 patients with NSCLC who underwent both dual-energy CT (DE-CT) and 18F-FDG PET/CT were included. A region of interest (ROI) encircling the entire primary tumor was delineated, and a rigid registration of the DE-CT, iodine maps and FDG images was performed for the ROI. The correlation between tumor measurements and area-specific measurements of ICpeak and the peak standardized uptake value (SUVpeak) was found. Finally, a correlation between tumor volume and the distance between SUVpeak and ICpeak centroids was found. (3) For the entire tumor, moderate-to-strong correlations were found between SUVmax and ICmax (R = 0.62, p = 0.002), and metabolic tumor volume vs. total iodine content (R = 0.91, p < 0.001), respectively. For local tumor sub-volumes, a negative correlation was found between ICpeak and SUVpeak (R = −0.58, p = 0.0046). Furthermore, a strong correlation was found between the tumor volume and the distance in millimeters between SUVpeak and ICpeak centroids (R = 0.81, p < 0.0001). (4) In patients with NSCLC, high FDG uptakes and high DE-CT-derived iodine concentrations correlated on a whole-tumor level, but the peak areas were positioned at different locations within the tumor. 18F-FDG PET/CT and DE-CT provide complementary information and might represent different underlying patho-physiologies. View Full-Text
Keywords: computed tomography; 18F-Flourodeoxyglucose PET/CT; lung cancer computed tomography; 18F-Flourodeoxyglucose PET/CT; lung cancer
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MDPI and ACS Style

Andersen, M.B.; Drljevic-Nielsen, A.; Thygesen, J.; Kruis, M.F.; Hjorthaug, K.; Rasmussen, F.; Nijkamp, J.A. Assessment of Correlation between Dual-Energy Ct (De-Ct)-Derived Iodine Concentration and Local Flourodeoxyglucose (Fdg) Uptake in Patients with Primary Non-Small-Cell Lung Cancer. Tomography 2022, 8, 1770-1780. https://doi.org/10.3390/tomography8040149

AMA Style

Andersen MB, Drljevic-Nielsen A, Thygesen J, Kruis MF, Hjorthaug K, Rasmussen F, Nijkamp JA. Assessment of Correlation between Dual-Energy Ct (De-Ct)-Derived Iodine Concentration and Local Flourodeoxyglucose (Fdg) Uptake in Patients with Primary Non-Small-Cell Lung Cancer. Tomography. 2022; 8(4):1770-1780. https://doi.org/10.3390/tomography8040149

Chicago/Turabian Style

Andersen, Michael Brun, Aska Drljevic-Nielsen, Jesper Thygesen, Matthijs Ferdinand Kruis, Karin Hjorthaug, Finn Rasmussen, and Jasper Albertus Nijkamp. 2022. "Assessment of Correlation between Dual-Energy Ct (De-Ct)-Derived Iodine Concentration and Local Flourodeoxyglucose (Fdg) Uptake in Patients with Primary Non-Small-Cell Lung Cancer" Tomography 8, no. 4: 1770-1780. https://doi.org/10.3390/tomography8040149

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