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Diagnostic Accuracy of Coronary Artery Occlusion and Myocardial Perfusion Defect on Non-Gated Enhanced Chest CT in Predicting Acute Myocardial Infarction

1
Department of Radiology, CHA University Bundang Medical Center, Seongnam 13497, Korea
2
Department of Radiology, University of Maryland, Baltimore, MD 20742, USA
*
Author to whom correspondence should be addressed.
These authors contributed equally to this article.
Academic Editor: Michail Plotkin
Tomography 2021, 7(4), 504-512; https://doi.org/10.3390/tomography7040043
Received: 11 August 2021 / Revised: 2 September 2021 / Accepted: 24 September 2021 / Published: 27 September 2021
The purpose of this study was to evaluate the diagnostic accuracy of coronary artery occlusion (CAO) and myocardial perfusion defect (MPD) identified on non-gated enhanced chest CT in patients with acute myocardial infarction (AMI). We retrospectively assessed 99 patients with AMI (group 1, n = 33) and without AMI (group 2, n = 66) who underwent non-gated chest CT. We analyzed the presence of MPD and CAO on non-gated chest CT. MPD on the CT was categorized using a three-point scale (0 = no definite MPD; 1 = probable artifact or questionable MPD; 2 = probable MPD). Presence of CAO was defined as an abrupt change of contrast enhancement in a coronary artery segment with no or minimal coronary motion on the CT. There were 42.4% and 12.1% patients with probable MPD (p = 0.002), and 18.2% and 0% patients with CAO (p = 0.001) in groups 1 and 2, respectively. Probable MPD alone and simultaneous presence of CAO and probable MPD to predict AMI resulted in sensitivity, specificity, negative predictive value, and positive predictive valve of 42.4%, 87.9%, 75.3%, and 63.6%, respectively, and 12.1%, 100%, 69.5%, and 100%, respectively. In conclusion, probable MPD alone on non-gated chest CT demonstrated a relatively low sensitivity, high specificity, and modest positive predictive value for the prediction of AMI on non-gated enhanced chest CT. Although it is rare, simultaneous presence of CAO and probable MPD had a high positive predictive value to predict AMI on non-gated enhanced chest CT. View Full-Text
Keywords: acute myocardial infarction; coronary artery occlusion; myocardial perfusion defect; chest CT; CT acute myocardial infarction; coronary artery occlusion; myocardial perfusion defect; chest CT; CT
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MDPI and ACS Style

Son, M.J.; Lee, D.; Yoo, S.M.; White, C.S. Diagnostic Accuracy of Coronary Artery Occlusion and Myocardial Perfusion Defect on Non-Gated Enhanced Chest CT in Predicting Acute Myocardial Infarction. Tomography 2021, 7, 504-512. https://doi.org/10.3390/tomography7040043

AMA Style

Son MJ, Lee D, Yoo SM, White CS. Diagnostic Accuracy of Coronary Artery Occlusion and Myocardial Perfusion Defect on Non-Gated Enhanced Chest CT in Predicting Acute Myocardial Infarction. Tomography. 2021; 7(4):504-512. https://doi.org/10.3390/tomography7040043

Chicago/Turabian Style

Son, Min J., Dongjun Lee, Seung M. Yoo, and Charles S. White 2021. "Diagnostic Accuracy of Coronary Artery Occlusion and Myocardial Perfusion Defect on Non-Gated Enhanced Chest CT in Predicting Acute Myocardial Infarction" Tomography 7, no. 4: 504-512. https://doi.org/10.3390/tomography7040043

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