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Tomography
Volume 5
Issue 2
10.18383/j.tom.2019.00004
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Tomography is published by MDPI from Volume 7 Issue 1 (2021). Previous articles were published by another publisher in Open Access under a CC-BY (or CC-BY-NC-ND) licence, and they are hosted by MDPI on mdpi.com as a courtesy and upon agreement with Grapho, LLC.
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Article

Use of Indicator Dilution Principle to Evaluate Accuracy of Arterial Input Function Measured With Low-Dose Ultrafast Prostate Dynamic Contrast-Enhanced MRI

by
Shiyang Wang
1,
Xiaobing Fan
1,
Yue Zhang
1,
Milica Medved
1,
Dianning He
1,2,
Ambereen Yousuf
1,
Ernest Jamison
1,
Aytekin Oto
1 and
Gregory S. Karczmar
1,*
1
Department of Radiology, University of Chicago, Chicago, IL, USA
2
Sino-Dutch Biomedical and Information Engineering School, Northeastern University, Shenyang, China
*
Author to whom correspondence should be addressed.
Tomography 2019, 5(2), 260-265; https://doi.org/10.18383/j.tom.2019.00004
Submission received: 2 March 2019 / Revised: 3 April 2019 / Accepted: 5 May 2019 / Published: 1 June 2019
Versions Notes

Abstract

Accurately measuring arterial input function (AIF) is essential for quantitative analysis of dynamic contrast-enhanced (DCE) magnetic resonance imaging (MRI). We used the indicator dilution principle to evaluate the accuracy of AIF measured directly from an artery following a low-dose contrast media ultrafast DCE-MRI. In total, 15 patients with biopsy-confirmed localized prostate cancers were recruited. Cardiac MRI (CMRI) and ultrafast DCE-MRI were acquired on a Philips 3 T Ingenia scanner. The AIF was measured at iliac arties following injection of a low-dose (0.015 mmol/kg) gadolinium (Gd) contrast media. The cardiac output (CO) from CMRI (COCMRI) was calculated from the difference in ventricular volume at diastole and systole measured on the short axis of heart. The CO from DCE-MRI (CODCE) was also calculated from the AIF and dose of the contrast media used. A correlation test and Bland–Altman plot were used to compare COCMRI and CODCE. The average (±standard deviation [SD]) area under the curve measured directly from local AIF was 0.219 ± 0.07 mM·min. The average (±SD) COCMRI and CODCE were 6.52 ± 1.47 L/min and 6.88 ± 1.64 L/min, respectively. There was a strong positive correlation (r = 0.82, P < .01) and good agreement between COCMRI and CODCE. The CODCE is consistent with the reference standard COCMRI. This indicates that the AIF can be measured accurately from an artery with ultrafast DCE-MRI following injection of a low-dose contrast media.
Keywords: arterial input function; low dose DCE-MRI; cardiac output; indicator dilution principle arterial input function; low dose DCE-MRI; cardiac output; indicator dilution principle

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MDPI and ACS Style

Wang, S.; Fan, X.; Zhang, Y.; Medved, M.; He, D.; Yousuf, A.; Jamison, E.; Oto, A.; Karczmar, G.S. Use of Indicator Dilution Principle to Evaluate Accuracy of Arterial Input Function Measured With Low-Dose Ultrafast Prostate Dynamic Contrast-Enhanced MRI. Tomography 2019, 5, 260-265. https://doi.org/10.18383/j.tom.2019.00004

AMA Style

Wang S, Fan X, Zhang Y, Medved M, He D, Yousuf A, Jamison E, Oto A, Karczmar GS. Use of Indicator Dilution Principle to Evaluate Accuracy of Arterial Input Function Measured With Low-Dose Ultrafast Prostate Dynamic Contrast-Enhanced MRI. Tomography. 2019; 5(2):260-265. https://doi.org/10.18383/j.tom.2019.00004

Chicago/Turabian Style

Wang, Shiyang, Xiaobing Fan, Yue Zhang, Milica Medved, Dianning He, Ambereen Yousuf, Ernest Jamison, Aytekin Oto, and Gregory S. Karczmar. 2019. "Use of Indicator Dilution Principle to Evaluate Accuracy of Arterial Input Function Measured With Low-Dose Ultrafast Prostate Dynamic Contrast-Enhanced MRI" Tomography 5, no. 2: 260-265. https://doi.org/10.18383/j.tom.2019.00004

APA Style

Wang, S., Fan, X., Zhang, Y., Medved, M., He, D., Yousuf, A., Jamison, E., Oto, A., & Karczmar, G. S. (2019). Use of Indicator Dilution Principle to Evaluate Accuracy of Arterial Input Function Measured With Low-Dose Ultrafast Prostate Dynamic Contrast-Enhanced MRI. Tomography, 5(2), 260-265. https://doi.org/10.18383/j.tom.2019.00004

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