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Article

A Web-Based Response-Assessment System for Development and Validation of Imaging Biomarkers in Oncology

Department of Radiology, Columbia University Medical Center, 710 West 168th Street, B26, New York, NY 10032, USA
*
Author to whom correspondence should be addressed.
Tomography 2019, 5(1), 220-225; https://doi.org/10.18383/j.tom.2019.00006
Submission received: 1 January 2019 / Revised: 17 January 2019 / Accepted: 20 February 2019 / Published: 1 March 2019

Abstract

Quantitative imaging biomarkers are increasingly used in oncology clinical trials to assist the evaluation of tumor responses to novel therapies. To identify these biomarkers and ensure smooth clinical translation once they have been validated, it is critical to develop a reliable workflow-efficient imaging platform for integration in clinical settings. Here we will present a web-based volumetric response-assessment system that we developed based on an open-source image viewing platform (WEASIS) and a DICOM image archive (DCM4CHEE). Our web-based response-assessment system offers a DICOM imaging archiving function, standard imaging viewing and manipulation functions, efficient tumor segmentation and quantification algorithms, and a reliable database containing tumor segmentation and measurement results. The prototype system is currently used in our research lab to foster the development and validation of new quantitative imaging biomarkers, including the volumetric computed tomography technique, as a more accurate and early assessment method of solid tumor responses to targeted and immunotherapies.
Keywords: quantitative imaging biomarkers; response assessment; web-based image platform quantitative imaging biomarkers; response assessment; web-based image platform

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MDPI and ACS Style

Yang, H.; Guo, X.; Schwartz, L.H.; Zhao, B. A Web-Based Response-Assessment System for Development and Validation of Imaging Biomarkers in Oncology. Tomography 2019, 5, 220-225. https://doi.org/10.18383/j.tom.2019.00006

AMA Style

Yang H, Guo X, Schwartz LH, Zhao B. A Web-Based Response-Assessment System for Development and Validation of Imaging Biomarkers in Oncology. Tomography. 2019; 5(1):220-225. https://doi.org/10.18383/j.tom.2019.00006

Chicago/Turabian Style

Yang, Hao, Xiaotao Guo, Lawrence H. Schwartz, and Binsheng Zhao. 2019. "A Web-Based Response-Assessment System for Development and Validation of Imaging Biomarkers in Oncology" Tomography 5, no. 1: 220-225. https://doi.org/10.18383/j.tom.2019.00006

APA Style

Yang, H., Guo, X., Schwartz, L. H., & Zhao, B. (2019). A Web-Based Response-Assessment System for Development and Validation of Imaging Biomarkers in Oncology. Tomography, 5(1), 220-225. https://doi.org/10.18383/j.tom.2019.00006

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