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Tomography
Volume 3
Issue 4
10.18383/j.tom.2017.00012
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Tomography is published by MDPI from Volume 7 Issue 1 (2021). Previous articles were published by another publisher in Open Access under a CC-BY (or CC-BY-NC-ND) licence, and they are hosted by MDPI on mdpi.com as a courtesy and upon agreement with Grapho, LLC.
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Article

Experimental MRI Monitoring of Renal Blood Volume Fraction Variations En Route to Renal Magnetic Resonance Oximetry

by
Andreas Pohlmann
1,*,
Kathleen Cantow
2,
Till Huelnhagen
1,
Dirk Grosenick
3,
Joāo dos Santos Periquito
1,
Laura Boehmert
1,
Thomas Gladytz
3,
Sonia Waiczies
1,
Bert Flemming
2,
Erdmann Seeliger
2 and
Thoralf Niendorf
1,4,5
1
Max Delbrück Center for Molecular Medicine in the Helmholtz Association, Berlin Ultrahigh Field Facility (B.U.F.F.), Berlin, Germany
2
Institute of Physiology and Center for Cardiovascular Research, Charité – Universitätsmedizin Berlin, Campus Charité Mitte, Berlin, Germany
3
Physikalisch-Technische-Bundesanstalt (PTB), Berlin, Germany
4
Experimental and Clinical Research Center, Charité Medical Faculty and the Max Delbrück Center for Molecular Medicine in the Helmholtz Association, Berlin, Germany
5
Deutsches Zentrum für Herz- Kreislauf-Forschung (DZHK; German Centre for Cardiovascular Research), Berlin, Germany
*
Author to whom correspondence should be addressed.
Tomography 2017, 3(4), 188-200; https://doi.org/10.18383/j.tom.2017.00012
Submission received: 5 September 2017 / Revised: 10 October 2017 / Accepted: 14 November 2017 / Published: 1 December 2017
Versions Notes

Abstract

Diagnosis of early-stage acute kidney injury (AKI) will benefit from a timely identification of local tissue hypoxia. Renal tissue hypoxia is an early feature in AKI pathophysiology, and renal oxygenation is increasingly being assessed through T2*-weighted magnetic resonance imaging (MRI). However, changes in renal blood volume fraction (BVf) confound renal T2*. The aim of this study was to assess the feasibility of intravascular contrast-enhanced MRI for monitoring renal BVf during physiological interventions that are concomitant with variations in BVf and to explore the possibility of correcting renal T2* for BVf variations. A dose-dependent study of the contrast agent ferumoxytol was performed in rats. BVf was monitored throughout short-term occlusion of the renal vein, which is known to markedly change renal blood partial pressure of O2 and BVf. BVf calculated from MRI measurements was used to estimate oxygen saturation of hemoglobin (SO2). BVf and SO2 were benchmarked against cortical data derived from near-infrared spectroscopy. As estimated from magnetic resonance parametric maps of T2*, BVf was shown to increase, whereas SO2 was shown to decline during venous occlusion (VO). This observation could be quantitatively reproduced in test–retest scenarios. Changes in BVf and SO2 were in good agreement with data obtained from near-infrared spectroscopy. Our findings provide motivation to advance multiparametric MRI for studying AKIs, with the ultimate goal of translating MRI-based renal BVf mapping into clinical practice en route noninvasive renal magnetic resonance oximetry as a method of assessing AKI and progression to chronic damage.
Keywords: kidney; oxygenation; blood volume fraction; magnetic resonance imaging; blood oxygenation level dependent (BOLD); ultrasmall superparamagnetic iron oxide (USPIO) kidney; oxygenation; blood volume fraction; magnetic resonance imaging; blood oxygenation level dependent (BOLD); ultrasmall superparamagnetic iron oxide (USPIO)

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MDPI and ACS Style

Pohlmann, A.; Cantow, K.; Huelnhagen, T.; Grosenick, D.; Periquito, J.d.S.; Boehmert, L.; Gladytz, T.; Waiczies, S.; Flemming, B.; Seeliger, E.; et al. Experimental MRI Monitoring of Renal Blood Volume Fraction Variations En Route to Renal Magnetic Resonance Oximetry. Tomography 2017, 3, 188-200. https://doi.org/10.18383/j.tom.2017.00012

AMA Style

Pohlmann A, Cantow K, Huelnhagen T, Grosenick D, Periquito JdS, Boehmert L, Gladytz T, Waiczies S, Flemming B, Seeliger E, et al. Experimental MRI Monitoring of Renal Blood Volume Fraction Variations En Route to Renal Magnetic Resonance Oximetry. Tomography. 2017; 3(4):188-200. https://doi.org/10.18383/j.tom.2017.00012

Chicago/Turabian Style

Pohlmann, Andreas, Kathleen Cantow, Till Huelnhagen, Dirk Grosenick, Joāo dos Santos Periquito, Laura Boehmert, Thomas Gladytz, Sonia Waiczies, Bert Flemming, Erdmann Seeliger, and et al. 2017. "Experimental MRI Monitoring of Renal Blood Volume Fraction Variations En Route to Renal Magnetic Resonance Oximetry" Tomography 3, no. 4: 188-200. https://doi.org/10.18383/j.tom.2017.00012

APA Style

Pohlmann, A., Cantow, K., Huelnhagen, T., Grosenick, D., Periquito, J. d. S., Boehmert, L., Gladytz, T., Waiczies, S., Flemming, B., Seeliger, E., & Niendorf, T. (2017). Experimental MRI Monitoring of Renal Blood Volume Fraction Variations En Route to Renal Magnetic Resonance Oximetry. Tomography, 3(4), 188-200. https://doi.org/10.18383/j.tom.2017.00012

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