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Tomography
Volume 3
Issue 4
10.18383/j.tom.2017.00016
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Tomography is published by MDPI from Volume 7 Issue 1 (2021). Previous articles were published by another publisher in Open Access under a CC-BY (or CC-BY-NC-ND) licence, and they are hosted by MDPI on mdpi.com as a courtesy and upon agreement with Grapho, LLC.
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Communication

High-Frequency 4-Dimensional Ultrasound (4DUS): A Reliable Method for Assessing Murine Cardiac Function

by
Frederick W. Damen
1,
Alycia G. Berman
1,
Arvin H. Soepriatna
1,
Jessica M. Ellis
2,
Stephen D. Buttars
3,
Kristiina L. Aasa
3 and
Craig J. Goergen
1,*
1
Weldon School of Biomedical Engineering, Purdue University, West Lafayette, IN, USA
2
Department of Nutrition Science, Purdue University, West Lafayette, IN, USA
3
FUJIFILM VisualSonics, Toronto, ON, Canada
*
Author to whom correspondence should be addressed.
Tomography 2017, 3(4), 180-187; https://doi.org/10.18383/j.tom.2017.00016
Submission received: 4 September 2017 / Revised: 9 October 2017 / Accepted: 6 November 2017 / Published: 1 December 2017
Versions Notes

Abstract

In vivo imaging has provided a unique framework for studying pathological progression in various mouse models of cardiac disease. Although conventional short-axis motion-mode (SAX MM) ultrasound and cine magnetic resonance imaging (MRI) are two of the most prevalent strategies used for quantifying cardiac function, there are few notable limitations including imprecision, inaccuracy, and geometric assumptions with ultrasound, or large and costly systems with substantial infrastructure requirements with MRI. Here we present an automated 4-dimensional ultrasound (4DUS) technique that provides comparable information to cine MRI through spatiotemporally synced imaging of cardiac motion. Cardiac function metrics derived from SAX MM, cine MRI, and 4DUS data show close agreement between cine MRI and 4DUS but overestimations by SAX MM. The inclusion of a mouse model of cardiac hypertrophy further highlights the precision of 4DUS compared with that of SAX MM, with narrower groupings of cardiac metrics based on health status. Our findings suggest that murine 4DUS can be used as a reliable, accurate, and cost-effective technique for longitudinal studies of cardiac function and disease progression.
Keywords: ultrasound; cine MRI; cardiac disease; mouse; hypertrophy ultrasound; cine MRI; cardiac disease; mouse; hypertrophy

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MDPI and ACS Style

Damen, F.W.; Berman, A.G.; Soepriatna, A.H.; Ellis, J.M.; Buttars, S.D.; Aasa, K.L.; Goergen, C.J. High-Frequency 4-Dimensional Ultrasound (4DUS): A Reliable Method for Assessing Murine Cardiac Function. Tomography 2017, 3, 180-187. https://doi.org/10.18383/j.tom.2017.00016

AMA Style

Damen FW, Berman AG, Soepriatna AH, Ellis JM, Buttars SD, Aasa KL, Goergen CJ. High-Frequency 4-Dimensional Ultrasound (4DUS): A Reliable Method for Assessing Murine Cardiac Function. Tomography. 2017; 3(4):180-187. https://doi.org/10.18383/j.tom.2017.00016

Chicago/Turabian Style

Damen, Frederick W., Alycia G. Berman, Arvin H. Soepriatna, Jessica M. Ellis, Stephen D. Buttars, Kristiina L. Aasa, and Craig J. Goergen. 2017. "High-Frequency 4-Dimensional Ultrasound (4DUS): A Reliable Method for Assessing Murine Cardiac Function" Tomography 3, no. 4: 180-187. https://doi.org/10.18383/j.tom.2017.00016

APA Style

Damen, F. W., Berman, A. G., Soepriatna, A. H., Ellis, J. M., Buttars, S. D., Aasa, K. L., & Goergen, C. J. (2017). High-Frequency 4-Dimensional Ultrasound (4DUS): A Reliable Method for Assessing Murine Cardiac Function. Tomography, 3(4), 180-187. https://doi.org/10.18383/j.tom.2017.00016

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