High-Resolution MR Imaging of Muscular Fat Fraction—Comparison of Three T2-Based Methods and Chemical Shift-Encoded Imaging

Trinh, Lena; Lind, Emelie; Peterson, Pernilla; Svensson, Jonas; Olsson, Lars E.; Månsson, Sven

doi:10.18383/j.tom.2017.00011

Open AccessArticle

High-Resolution MR Imaging of Muscular Fat Fraction—Comparison of Three T₂-Based Methods and Chemical Shift-Encoded Imaging

by

Lena Trinh

^1,*,

Emelie Lind

^1,2,

Pernilla Peterson

¹,

Jonas Svensson

^1,3,

Lars E. Olsson

¹ and

Sven Månsson

¹

Medical Radiation Physics, Department of Translational Medicine, Lund University, Skåne University Hospital, Malmö, Sweden

²

Department of Medical Radiation Physics, Lund University, Lund, Sweden

³

Medical Imaging and Physiology, Skåne University Hospital, Lund, Sweden

^*

Author to whom correspondence should be addressed.

Tomography 2017, 3(3), 153-162; https://doi.org/10.18383/j.tom.2017.00011

Submission received: 3 June 2017 / Revised: 4 July 2017 / Accepted: 10 August 2017 / Published: 1 September 2017

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Abstract

Chemical shift-encoded imaging (CSEI) is the most common magnetic resonance imaging fat–water separation method. However, when high spatial resolution fat fraction (FF) images are desired, CSEI might be challenging owing to the increased interecho spacing. Here, 3 T₂-based methods have been assessed as alternative methods for obtaining high-resolution FF images. Images from the calf of 10 healthy volunteers were acquired; FF maps were then estimated using 3 T₂-based methods (2- and 3-parameter nonlinear least squares fit and a Bayesian probability method) and CSEI for reference. In addition, simulations were conducted to characterize the performance of various methods. Here, all T₂-based methods resulted in qualitatively improved high-resolution FF images compared with high-resolution CSEI. The 2-parameter fit showed best quantitative agreement to low-resolution CSEI, even at low FF. The estimated T₂-values of fat and water, and the estimated muscle FF of the calf, agreed well with previously published data. In conclusion, T₂-based methods can provide improved high-resolution FF images of the calf compared with the CSEI method.

Keywords: fat quantification; Bayesian probability theory; non-linear least squares; high-resolution imaging

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MDPI and ACS Style

Trinh, L.; Lind, E.; Peterson, P.; Svensson, J.; Olsson, L.E.; Månsson, S. High-Resolution MR Imaging of Muscular Fat Fraction—Comparison of Three T₂-Based Methods and Chemical Shift-Encoded Imaging. Tomography 2017, 3, 153-162. https://doi.org/10.18383/j.tom.2017.00011

AMA Style

Trinh L, Lind E, Peterson P, Svensson J, Olsson LE, Månsson S. High-Resolution MR Imaging of Muscular Fat Fraction—Comparison of Three T₂-Based Methods and Chemical Shift-Encoded Imaging. Tomography. 2017; 3(3):153-162. https://doi.org/10.18383/j.tom.2017.00011

Chicago/Turabian Style

Trinh, Lena, Emelie Lind, Pernilla Peterson, Jonas Svensson, Lars E. Olsson, and Sven Månsson. 2017. "High-Resolution MR Imaging of Muscular Fat Fraction—Comparison of Three T₂-Based Methods and Chemical Shift-Encoded Imaging" Tomography 3, no. 3: 153-162. https://doi.org/10.18383/j.tom.2017.00011

APA Style

Trinh, L., Lind, E., Peterson, P., Svensson, J., Olsson, L. E., & Månsson, S. (2017). High-Resolution MR Imaging of Muscular Fat Fraction—Comparison of Three T₂-Based Methods and Chemical Shift-Encoded Imaging. Tomography, 3(3), 153-162. https://doi.org/10.18383/j.tom.2017.00011

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High-Resolution MR Imaging of Muscular Fat Fraction—Comparison of Three T₂-Based Methods and Chemical Shift-Encoded Imaging

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