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10.18383/j.tom.2016.00229
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Article

Comparison between 3-Scan Trace and Diagonal Body Diffusion-Weighted Imaging Acquisitions: A Phantom and Volunteer Study

by
Stefanie J. Hectors
1,2,*,
Mathilde Wagner
1,2,
Idoia Corcuera-Solano
1,2,
Martin Kang
3,
Alto Stemmer
4,
Michael A. Boss
5 and
Bachir Taouli
1,2
1
Translational and Molecular Imaging Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA
2
Department of Radiology and Translational and Molecular Imaging Institute, Icahn School of Medicine at Mount Sinai, 1 Gustave L. Levy Place, Box 1234, New York, NY 10029, USA
3
Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA
4
Siemens AG, Medical Solutions, Magnetic Resonance, Erlangen, Germany
5
Applied Physics Division, National Institute of Standards and Technology, Boulder, CO, USA
*
Author to whom correspondence should be addressed.
Tomography 2016, 2(4), 411-420; https://doi.org/10.18383/j.tom.2016.00229
Submission received: 5 September 2016 / Revised: 6 October 2016 / Accepted: 3 November 2016 / Published: 1 December 2016
Versions Notes

Abstract

Diagonal diffusion-weighted imaging (dDWI) uses simultaneous maximized application of 3 orthogonal gradient systems as opposed to sequential acquisition in 3 directions in conventional 3-scan trace DWI (tDWI). Several theoretical advantages of dDWI vs. tDWI include reduced artifacts and increased sharpness. We compared apparent diffusion coefficient (ADC) quantification and image quality between monopolar dDWI and tDWI in a dedicated diffusion phantom (b = 0/500/900/2000 s/mm2) and in the abdomen (b = 50/400/800 s/mm2) and pelvis (b = 50/1000/1600 s/mm2) of 2 male volunteers at 1.5 T and 3.0 T. Phantom estimated signal-to-noise ratio (eSNR) was also measured. Two independent observers assessed the image quality on a 5-point scale. In the phantom, image quality was similar between tDWI and dDWI, with equivalent ADC quantification (mean coefficient of variation [CV] between sequences: 1.4% ± 1.2% at 1.5 T and 0.7% ± 0.7% at 3.0 T). Phantom eSNR was similar for both tDWI and dDWI, except for a significantly lower eSNR for b900 of dDWI at 3.0 T (P = .006). In the volunteers, the CV values between tDWI and dDWI were higher than those in the phantom (CV range: abdominal organs, 1.3%–13.3%; pelvic organs, 0.6%–5.7%). A trend toward significant better image quality for dDWI compared with tDWI was observed for b800 (abdomen) at 3.0 T and for b1000 and b1600 (pelvis) at 1.5 T (P = .063 to .066). Our data suggest that dDWI may provide better image quality than tDWI without affecting ADC quantification, needing confirmation in a future clinical study.
Keywords: diffusion-weighted imaging; phantom; volunteers; apparent diffusion coefficient diffusion-weighted imaging; phantom; volunteers; apparent diffusion coefficient

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MDPI and ACS Style

Hectors, S.J.; Wagner, M.; Corcuera-Solano, I.; Kang, M.; Stemmer, A.; Boss, M.A.; Taouli, B. Comparison between 3-Scan Trace and Diagonal Body Diffusion-Weighted Imaging Acquisitions: A Phantom and Volunteer Study. Tomography 2016, 2, 411-420. https://doi.org/10.18383/j.tom.2016.00229

AMA Style

Hectors SJ, Wagner M, Corcuera-Solano I, Kang M, Stemmer A, Boss MA, Taouli B. Comparison between 3-Scan Trace and Diagonal Body Diffusion-Weighted Imaging Acquisitions: A Phantom and Volunteer Study. Tomography. 2016; 2(4):411-420. https://doi.org/10.18383/j.tom.2016.00229

Chicago/Turabian Style

Hectors, Stefanie J., Mathilde Wagner, Idoia Corcuera-Solano, Martin Kang, Alto Stemmer, Michael A. Boss, and Bachir Taouli. 2016. "Comparison between 3-Scan Trace and Diagonal Body Diffusion-Weighted Imaging Acquisitions: A Phantom and Volunteer Study" Tomography 2, no. 4: 411-420. https://doi.org/10.18383/j.tom.2016.00229

APA Style

Hectors, S. J., Wagner, M., Corcuera-Solano, I., Kang, M., Stemmer, A., Boss, M. A., & Taouli, B. (2016). Comparison between 3-Scan Trace and Diagonal Body Diffusion-Weighted Imaging Acquisitions: A Phantom and Volunteer Study. Tomography, 2(4), 411-420. https://doi.org/10.18383/j.tom.2016.00229

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