Preliminary Results of Clinical Experience with Consolidative High-Dose Thoracic Radiotherapy for Patients with Extensive-Stage Small Cell Lung Cancer
Abstract
:1. Introduction
2. Materials and Methods
2.1. Patients
2.2. Treatment Scheme
2.3. Surveillance
2.4. Statistical Analyses
3. Results
3.1. Baseline Characteristics
3.2. Patterns of Failure
3.3. Treatment-Related Complications and Survival Outcomes
4. Discussion
5. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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Characteristics | Number | % |
---|---|---|
Age [years; median (range)] | 66 (51–79) | |
Sex | ||
Female | 4 | 18.2% |
Male | 18 | 81.8% |
Smoking Status | ||
Never smoker | 2 | 9.1% |
Current or Ex-smoker | 20 | 90.9% |
ECOG performance status | ||
0–1 | 22 | 100% |
2 | 0 | 0% |
Underlying pulmonary disease | ||
None | 14 | 63.6% |
COPD | 7 | 31.8% |
IPF | 1 | 4.6% |
Number of metastatic sites at diagnosis | ||
Single | 12 | 54.5% |
Multiple | 10 | 45.5% |
M Stage_8th Edition, AJCC | ||
M1a | 9 | 40.9% |
M1b | 3 | 13.6% |
M1c | 10 | 45.5% |
Immuno-oncologic agent treatment | ||
No | 2 | 9.1% |
Yes | 20 | 90.9% |
Response to prior systemic treatment | ||
Partial response/Stable disease | 12 | 54.5% |
Oligo-progressive disease | 10 | 45.5% |
No. | Age/Sex | Smoking | Underlying Disease | Metastatic Site(s) | Chemotherapy Regimen | Time to Radiotherapy (Months) | Radiotherapy Site(s) | Current Status |
---|---|---|---|---|---|---|---|---|
1 | 67/M | Ex- | COPD | Pleura, Bone | Atezo + EP | 5 | Lung, MLN | LRR (SCN), AWD |
2 | 72/M | Current- | None | Lung, Liver | Atezo + EP | 8 | MLN, SCN | DM (lung), DOD |
3 | 51/M | Ex- | COPD | Pleura | Atezo + EP | 14 | MLN | AWD |
4 | 62/M | Ex- | COPD | Brain, Adrenal gland | Atezo + EP | 28 | Lung, MLN | AWD |
5 | 75/M | Current- | None | Pleura | Atezo + EP | 15 | Lung, MLN | DM (lung), DOD |
6 | 65/F | Current- | COPD | Lung, lymph node | Atezo + EP | 10 | Lung | DM (lung), DOD |
7 | 56/M | Ex- | None | Pleura | Atezo + EP | 6 | MLN, SCN | LRR (primary lung), AWD |
8 | 55/F | Never- | None | Brain | Atezo + EP | 8 | Lung | RR (MLN), DOD |
9 | 65/M | Ex- | COPD | Pleura, Bone | Atezo + EP | 10 | MLN | DM (lung), DOD |
10 | 69/M | Ex- | None | Brain, lymph node | Atezo + EP | 5 | MLN | DM (spinal cord), AWD |
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Kim, H.; Hwang, J.; Kim, S.M.; Yang, D.S. Preliminary Results of Clinical Experience with Consolidative High-Dose Thoracic Radiotherapy for Patients with Extensive-Stage Small Cell Lung Cancer. Tomography 2025, 11, 55. https://doi.org/10.3390/tomography11050055
Kim H, Hwang J, Kim SM, Yang DS. Preliminary Results of Clinical Experience with Consolidative High-Dose Thoracic Radiotherapy for Patients with Extensive-Stage Small Cell Lung Cancer. Tomography. 2025; 11(5):55. https://doi.org/10.3390/tomography11050055
Chicago/Turabian StyleKim, Hakyoung, Jeongeun Hwang, Sun Myung Kim, and Dae Sik Yang. 2025. "Preliminary Results of Clinical Experience with Consolidative High-Dose Thoracic Radiotherapy for Patients with Extensive-Stage Small Cell Lung Cancer" Tomography 11, no. 5: 55. https://doi.org/10.3390/tomography11050055
APA StyleKim, H., Hwang, J., Kim, S. M., & Yang, D. S. (2025). Preliminary Results of Clinical Experience with Consolidative High-Dose Thoracic Radiotherapy for Patients with Extensive-Stage Small Cell Lung Cancer. Tomography, 11(5), 55. https://doi.org/10.3390/tomography11050055