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10.18383/j.tom.2015.00169
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Tomography is published by MDPI from Volume 7 Issue 1 (2021). Previous articles were published by another publisher in Open Access under a CC-BY (or CC-BY-NC-ND) licence, and they are hosted by MDPI on mdpi.com as a courtesy and upon agreement with Grapho, LLC.
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Interesting Images

Uptake of [18F]DCFPyL in Paget's Disease of Bone, an Important Potential Pitfall in the Clinical Interpretation of PSMA PET Studies

by
Steven P. Rowe
1,*,
Curtiland Deville
2,
Channing Paller
3,
Steve Y. Cho
5,
Elliot K. Fishman
1,
Martin G. Pomper
1,3,
Ashley E. Ross
4 and
Michael A. Gorin
4,*
1
Russell H. Morgan Department of Radiology and Radiological Science
2
Department of Radiation Oncology and Molecular Radiation Sciences
3
Sidney Kimmel Comprehensive Cancer Center
4
The James Buchanan Brady Urological Institute and Department of Urology, Johns Hopkins University School of Medicine, Baltimore, MD, USA
5
Department of Radiology, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA
*
Authors to whom correspondence should be addressed.
Tomography 2015, 1(2), 81-84; https://doi.org/10.18383/j.tom.2015.00169
Submission received: 8 September 2015 / Revised: 7 October 2015 / Accepted: 10 November 2015 / Published: 1 December 2015
Versions Notes

Abstract

Prostate-specific membrane antigen (PSMA)-targeted positron emission tomography (PET) imaging is an emerging technique for evaluating patients with prostate cancer (PCa) in a variety of clinical contexts. As with any new imaging modality, there are interpretive pitfalls that are beginning to be recognized. In this report, we describe the findings in a 63-year-old male with biochemically recurrent PCa after radical prostatectomy who was imaged with 2-(3-{1-carboxy-5-[(6-[18F]fluoro-pyridine-3-carbonyl)-amino]-pentyl}-ureido)-pentanedioic acid ([18F]DCFPyL), a small-molecule inhibitor of PSMA. Diffuse radiotracer uptake was noted throughout the sacrum, corresponding to imaging findings on contrast-enhanced computed tomography (CT), bone scan, and pelvic magnetic resonance imaging consistent with Paget's disease of bone. The uptake of [18F]DCFPyL in Paget's disease most likely results from hyperemia and increased radiotracer delivery. In light of the overlap in patients affected by PCa and Paget's disease, it is important for nuclear medicine physicians and radiologists to be aware of the potential for this diagnostic pitfall when interpreting PSMA PET/CT scans. Correlating findings on conventional imaging such as diagnostic CT and bone scan can help confirm the diagnosis.
Keywords: prostate cancer; PET; PSMA; DCFPyL prostate cancer; PET; PSMA; DCFPyL

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MDPI and ACS Style

Rowe, S.P.; Deville, C.; Paller, C.; Cho, S.Y.; Fishman, E.K.; Pomper, M.G.; Ross, A.E.; Gorin, M.A. Uptake of [18F]DCFPyL in Paget's Disease of Bone, an Important Potential Pitfall in the Clinical Interpretation of PSMA PET Studies. Tomography 2015, 1, 81-84. https://doi.org/10.18383/j.tom.2015.00169

AMA Style

Rowe SP, Deville C, Paller C, Cho SY, Fishman EK, Pomper MG, Ross AE, Gorin MA. Uptake of [18F]DCFPyL in Paget's Disease of Bone, an Important Potential Pitfall in the Clinical Interpretation of PSMA PET Studies. Tomography. 2015; 1(2):81-84. https://doi.org/10.18383/j.tom.2015.00169

Chicago/Turabian Style

Rowe, Steven P., Curtiland Deville, Channing Paller, Steve Y. Cho, Elliot K. Fishman, Martin G. Pomper, Ashley E. Ross, and Michael A. Gorin. 2015. "Uptake of [18F]DCFPyL in Paget's Disease of Bone, an Important Potential Pitfall in the Clinical Interpretation of PSMA PET Studies" Tomography 1, no. 2: 81-84. https://doi.org/10.18383/j.tom.2015.00169

APA Style

Rowe, S. P., Deville, C., Paller, C., Cho, S. Y., Fishman, E. K., Pomper, M. G., Ross, A. E., & Gorin, M. A. (2015). Uptake of [18F]DCFPyL in Paget's Disease of Bone, an Important Potential Pitfall in the Clinical Interpretation of PSMA PET Studies. Tomography, 1(2), 81-84. https://doi.org/10.18383/j.tom.2015.00169

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