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Tomography
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10.18383/j.tom.2015.00151
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Tomography is published by MDPI from Volume 7 Issue 1 (2021). Previous articles were published by another publisher in Open Access under a CC-BY (or CC-BY-NC-ND) licence, and they are hosted by MDPI on mdpi.com as a courtesy and upon agreement with Grapho, LLC.
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Article

Effect of 18F-FDG Uptake Time on Lesion Detectability in PET Imaging of Early-Stage Breast Cancer

by
Kristen A. Wangerin
1,
Mark Muzi
2,
Lanell M. Peterson
2,
Hannah M. Linden
3,
Alena Novakova
3,
Finbarr O'Sullivan
4,
Brenda F. Kurland
5,
David A. Mankoff
6 and
Paul E. Kinahan
1,2,*
1
Departments of Bioengineering, University of Washington, Seattle, WA, USA
2
Departments of Radiology, University of Washington, Seattle, WA, USA
3
Departments of Medicine, University of Washington, Seattle, WA, USA
4
Department of Statistics, University of Cork, Cork, Ireland
5
Department of Biostatistics, University of Pittsburgh, Pittsburgh, PA, USA
6
Department of Radiology, University of Pennsylvania, Philadelphia, PA, USA
*
Author to whom correspondence should be addressed.
Tomography 2015, 1(1), 53-60; https://doi.org/10.18383/j.tom.2015.00151
Submission received: 4 June 2015 / Revised: 8 July 2015 / Accepted: 10 August 2015 / Published: 1 September 2015
Versions Notes

Abstract

Prior reports have suggested that delayed 18F-fluorodeoxyglucose positron emission tomography (FDG-PET) oncology imaging can improve the contrast-to-noise ratio (CNR) for known lesions. Our goal was to estimate realistic bounds for lesion detectability for static measurements within 1 to 4 hours between FDG injection and image acquisition. Tumor and normal tissue kinetic model parameters were estimated from dynamic PET studies of patients with early-stage breast cancer. These parameters were used to generate time-activity curves (TACs) for up to 4 hours, for which we assumed both nonreversible and reversible models with different rates of FDG dephosphorylation (k4). For each pair of tumor and normal tissue TACs, 600 PET sinogram realizations were generated, and images were reconstructed using the ordered subsets expectation maximization reconstruction algorithm. Test statistics for each tumor and normal tissue region of interest were output from the computer model observers and evaluated using a receiver operating characteristic analysis, with the calculated area under the curve (AUC) providing a measure of lesion detectability. For the nonreversible model (k4 = 0), the AUC increased in 11 of 23 (48%) patients for 1 to 2 hours after the current standard postradiotracer injection imaging window of 1 hour. This improvement was driven by increased tumor/normal tissue contrast before the impact of increased noise that resulted from radiotracer decay began to dominate the imaging signal. As k4 was increased from 0 to 0.01 min−1, the time of maximum detectability shifted earlier, due to decreasing FDG concentration in the tumor lowering the CNR. These results imply that delayed PET imaging may reveal inconspicuous lesions that otherwise would have gone undetected.
Keywords: physics; PET; breast imaging; lesion detectability; virtual clinical trial physics; PET; breast imaging; lesion detectability; virtual clinical trial

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MDPI and ACS Style

Wangerin, K.A.; Muzi, M.; Peterson, L.M.; Linden, H.M.; Novakova, A.; O'Sullivan, F.; Kurland, B.F.; Mankoff, D.A.; Kinahan, P.E. Effect of 18F-FDG Uptake Time on Lesion Detectability in PET Imaging of Early-Stage Breast Cancer. Tomography 2015, 1, 53-60. https://doi.org/10.18383/j.tom.2015.00151

AMA Style

Wangerin KA, Muzi M, Peterson LM, Linden HM, Novakova A, O'Sullivan F, Kurland BF, Mankoff DA, Kinahan PE. Effect of 18F-FDG Uptake Time on Lesion Detectability in PET Imaging of Early-Stage Breast Cancer. Tomography. 2015; 1(1):53-60. https://doi.org/10.18383/j.tom.2015.00151

Chicago/Turabian Style

Wangerin, Kristen A., Mark Muzi, Lanell M. Peterson, Hannah M. Linden, Alena Novakova, Finbarr O'Sullivan, Brenda F. Kurland, David A. Mankoff, and Paul E. Kinahan. 2015. "Effect of 18F-FDG Uptake Time on Lesion Detectability in PET Imaging of Early-Stage Breast Cancer" Tomography 1, no. 1: 53-60. https://doi.org/10.18383/j.tom.2015.00151

APA Style

Wangerin, K. A., Muzi, M., Peterson, L. M., Linden, H. M., Novakova, A., O'Sullivan, F., Kurland, B. F., Mankoff, D. A., & Kinahan, P. E. (2015). Effect of 18F-FDG Uptake Time on Lesion Detectability in PET Imaging of Early-Stage Breast Cancer. Tomography, 1(1), 53-60. https://doi.org/10.18383/j.tom.2015.00151

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