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Improving Tomographic Reconstruction from Limited Data Using Mixed-Scale Dense Convolutional Neural Networks

Centrum Wiskunde & Informatica, Science Park 123, 1098 XG Amsterdam, The Netherlands
Department of Mathematics, University of California, Berkeley, CA 94720, USA
Center for Applied Mathematics for Energy Research Applications, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA
Author to whom correspondence should be addressed.
J. Imaging 2018, 4(11), 128;
Received: 1 September 2018 / Revised: 25 September 2018 / Accepted: 10 October 2018 / Published: 30 October 2018
PDF [49504 KB, uploaded 30 October 2018]


In many applications of tomography, the acquired data are limited in one or more ways due to unavoidable experimental constraints. In such cases, popular direct reconstruction algorithms tend to produce inaccurate images, and more accurate iterative algorithms often have prohibitively high computational costs. Using machine learning to improve the image quality of direct algorithms is a recently proposed alternative, for which promising results have been shown. However, previous attempts have focused on using encoder–decoder networks, which have several disadvantages when applied to large tomographic images, preventing wide application in practice. Here, we propose the use of the Mixed-Scale Dense convolutional neural network architecture, which was specifically designed to avoid these disadvantages, to improve tomographic reconstruction from limited data. Results are shown for various types of data limitations and object types, for both simulated data and large-scale real-world experimental data. The results are compared with popular tomographic reconstruction algorithms and machine learning algorithms, showing that Mixed-Scale Dense networks are able to significantly improve reconstruction quality even with severely limited data, and produce more accurate results than existing algorithms. View Full-Text
Keywords: machine learning; deep learning; image reconstruction; tomography machine learning; deep learning; image reconstruction; tomography

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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Pelt, D.M.; Batenburg, K.J.; Sethian, J.A. Improving Tomographic Reconstruction from Limited Data Using Mixed-Scale Dense Convolutional Neural Networks. J. Imaging 2018, 4, 128.

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