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Improved 19F{1H} Saturation Transfer Difference Experiments for Sensitive Detection to Fluorinated Compound Bound to Proteins

1
Division of Agriculture and Agricultural Life Sciences, The University of Tokyo, Yayoi, Bunkyo-ku, Tokyo 113-8657, Japan
2
Department of Chemistry, College of Science and Technology, Meisei University, Hino, Tokyo 191-8506, Japan
*
Author to whom correspondence should be addressed.
Magnetochemistry 2019, 5(1), 1; https://doi.org/10.3390/magnetochemistry5010001
Received: 24 October 2018 / Revised: 14 December 2018 / Accepted: 20 December 2018 / Published: 21 December 2018
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Abstract

The 19F{1H} saturation transfer difference (STD) method was improved for sensitive 19F detection using a human serum albumin-diflunisal complex. Because NMR (nuclear magnetic resonance) experiments with 19F detection are feasible for the selective detection of fluorinated compounds, more sensitive NMR methods are required to be developed for purposes of practicality. The present research focused on the investigations of 19F{1H} STD pulse techniques and experimental parameters, leading to the development of detection methods with higher sensitivity. View Full-Text
Keywords: NMR-based screening; fluorinated compound; diflunisal; 19F NMR; shaped pulses NMR-based screening; fluorinated compound; diflunisal; 19F NMR; shaped pulses
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
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Furihata, K.; Tashiro, M. Improved 19F{1H} Saturation Transfer Difference Experiments for Sensitive Detection to Fluorinated Compound Bound to Proteins. Magnetochemistry 2019, 5, 1.

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