Biological Thermal Performance of Organic and Inorganic Aerogels as Patches for Photothermal Therapy
Abstract
:1. Introduction
2. Results and Discussion
2.1. Physicochemical Characterization
2.2. Biological Performance of Aerogels When Combined with NIR Irradiation
2.3. Preliminary In Vivo Safety Assays Using Artemia salina Model
2.4. Human Skin Compatibility Tests
3. Conclusions
4. Materials and Methods
4.1. Materials
4.2. Preparation of Pectin-Based Structures
4.2.1. Pectin Hydrogel Preparation
4.2.2. Supercritical Drying
4.3. Preparation of Silica-Based Structures
4.4. Physicochemical Characterization of the Aerogels
4.5. Biological Performance of Aerogels When Combined with NIR Irradiation
4.6. Preliminary In Vivo Safety Assays Using Artemia salina Model
4.7. Human Skin Compatibility Tests
4.8. Statistical Analysis
Supplementary Materials
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
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Aerogel | Volume Shrinkage % | ρbulk (g cm−3) | ABET (m2 g−1) | Vp,BJH (cm3 g−1) | dp,BJH (nm) |
---|---|---|---|---|---|
Pectin-based | 83.5 ± 5.5 | 0.334 ± 0.092 | 330 ± 17 | 1.3 ± 0.1 | 10.3 ± 0.5 |
Silica-based | 21.8 ± 2.8 **** | 0.159 ± 0.009 | 726 ± 36 **** | 2.4 ± 0.1 | 9.1 ± 0.5 |
Test Group | Non-Irradiated | Irradiated |
---|---|---|
Only human skin | NO | ++ |
Human skin + Pectin-based aerogel | + | +++ |
Human skin + Silica-based aerogel | + | +++ |
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Ferreira-Gonçalves, T.; Iglesias-Mejuto, A.; Linhares, T.; Coelho, J.M.P.; Vieira, P.; Faísca, P.; Catarino, J.; Pinto, P.; Ferreira, D.; Ferreira, H.A.; et al. Biological Thermal Performance of Organic and Inorganic Aerogels as Patches for Photothermal Therapy. Gels 2022, 8, 485. https://doi.org/10.3390/gels8080485
Ferreira-Gonçalves T, Iglesias-Mejuto A, Linhares T, Coelho JMP, Vieira P, Faísca P, Catarino J, Pinto P, Ferreira D, Ferreira HA, et al. Biological Thermal Performance of Organic and Inorganic Aerogels as Patches for Photothermal Therapy. Gels. 2022; 8(8):485. https://doi.org/10.3390/gels8080485
Chicago/Turabian StyleFerreira-Gonçalves, Tânia, Ana Iglesias-Mejuto, Teresa Linhares, João M. P. Coelho, Pedro Vieira, Pedro Faísca, José Catarino, Pedro Pinto, David Ferreira, Hugo A. Ferreira, and et al. 2022. "Biological Thermal Performance of Organic and Inorganic Aerogels as Patches for Photothermal Therapy" Gels 8, no. 8: 485. https://doi.org/10.3390/gels8080485