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Article

Biocompatible Chitosan-Based Hydrogels for Bioabsorbable Wound Dressings

1
“Petru Poni” Institute of Macromolecular Chemistry, Gr. Ghica Voda Alley, 41A, 700487 Iasi, Romania
2
School of Engineering, Swiss Federal Institute of Technology (EPFL), 1015 Lausanne, Switzerland
3
Division Radio Monitoring and Equipment, Section Market Access and Conformity, Federal Office of Communications (OFCOM), 2501 Bienne, Switzerland
4
Doctoral School, Faculty of Applied Sciences, University Politehnica of Bucharest, 060042 Bucharest, Romania
5
Five Rescue Research Laboratory, 75004 Paris, France
6
Physics Department, Faculty of Applied Sciences, University Politehnica of Bucharest, 060042 Bucharest, Romania
7
Academy of Romanian Scientists, 50085 Bucharest, Romania
*
Author to whom correspondence should be addressed.
Academic Editor: Damien Dupin
Gels 2022, 8(2), 107; https://doi.org/10.3390/gels8020107
Received: 21 January 2022 / Revised: 1 February 2022 / Accepted: 7 February 2022 / Published: 10 February 2022
Supramolecular hydrogels based on chitosan and monoaldehydes are biomaterials with high potential for a multitude of bioapplications. This is due to the proper choice of the monoaldehyde that can tune the hydrogel properties for specific practices. In this conceptual framework, the present paper deals with the investigation of a hydrogel as bioabsorbable wound dressing. To this aim, chitosan was cross-linked with 2-formylphenylboronic acid to yield a hydrogel with antimicrobial activity. FTIR, NMR, and POM procedures have characterized the hydrogel from a structural and supramolecular point of view. At the same time, its biocompatibility and antimicrobial properties were also determined in vitro. Furthermore, in order to assess the bioabsorbable character, its biodegradation was investigated in vitro in the presence of lysosome in media of different pH, mimicking the wound exudate at different stages of healing. The biodegradation was monitored by gravimetrical measurements, SEM microscopy and fractal analyses of the images. The fractal dimension values and the lacunarity of SEM pictures were accurately calculated. All these successful investigations led to the conclusion that the tested materials are at the expected high standards. View Full-Text
Keywords: hydrogel; biocompatibility; antimicrobial activity; biodegradation; SEM image; fractal analysis hydrogel; biocompatibility; antimicrobial activity; biodegradation; SEM image; fractal analysis
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MDPI and ACS Style

Lungu, R.; Paun, M.-A.; Peptanariu, D.; Ailincai, D.; Marin, L.; Nichita, M.-V.; Paun, V.-A.; Paun, V.-P. Biocompatible Chitosan-Based Hydrogels for Bioabsorbable Wound Dressings. Gels 2022, 8, 107. https://doi.org/10.3390/gels8020107

AMA Style

Lungu R, Paun M-A, Peptanariu D, Ailincai D, Marin L, Nichita M-V, Paun V-A, Paun V-P. Biocompatible Chitosan-Based Hydrogels for Bioabsorbable Wound Dressings. Gels. 2022; 8(2):107. https://doi.org/10.3390/gels8020107

Chicago/Turabian Style

Lungu, Ramona, Maria-Alexandra Paun, Dragos Peptanariu, Daniela Ailincai, Luminita Marin, Mihai-Virgil Nichita, Vladimir-Alexandru Paun, and Viorel-Puiu Paun. 2022. "Biocompatible Chitosan-Based Hydrogels for Bioabsorbable Wound Dressings" Gels 8, no. 2: 107. https://doi.org/10.3390/gels8020107

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