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Article

Dynamics of a Gel-Based Artificial Tear Film with an Emphasis on Dry Disease Treatment Applications

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Laboratoire de Mécanique, Matériaux et Energétique, Faculté de Technologie, Université de Bejaia, Bejaia 06000, Algeria
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Department of Mechanical Engineering, Khalifa University, Abu Dhabi P.O. Box 127788, United Arab Emirates
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Univ. Grenoble Alpes, CNRS, Grenoble INP, LRP, 38000 Grenoble, France
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Laboratoire de Recherche en Hydraulique Appliquée et Environnement, Faculté de Technologie, Université de Bejaia, Bejaia 06000, Algeria
*
Author to whom correspondence should be addressed.
Academic Editors: Jingliang Li and Di Jia
Gels 2021, 7(4), 215; https://doi.org/10.3390/gels7040215
Received: 19 September 2021 / Revised: 1 November 2021 / Accepted: 2 November 2021 / Published: 16 November 2021
(This article belongs to the Special Issue Dynamics of Gels and Its Applications)
This paper discusses the spreading of gel-based ophthalmic formulation on the cornea surface assumed to be flat. We show that gel-based formulations exhibit rheological behaviors that the Herschel–Bulkley model can describe. The continuity and momentum equations are solved numerically using the monofluid formulation and the volume-of-fluid (VOF) method. We investigated the influence of the rheological properties, namely the consistency, the yield stress, and the flow behavior index, on the spreading of a gel-based artificial tear over the cornea surface. We propose optimal values of these properties for efficient gel-based artificial tears. View Full-Text
Keywords: dry eye disease; gel-based artificial tears; Herschel–Bulkley model; tear film breakup; VOF method dry eye disease; gel-based artificial tears; Herschel–Bulkley model; tear film breakup; VOF method
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MDPI and ACS Style

Mehdaoui, H.; Ait Abderrahmane, H.; de Loubens, C.; Nait Bouda, F.; Hamani, S. Dynamics of a Gel-Based Artificial Tear Film with an Emphasis on Dry Disease Treatment Applications. Gels 2021, 7, 215. https://doi.org/10.3390/gels7040215

AMA Style

Mehdaoui H, Ait Abderrahmane H, de Loubens C, Nait Bouda F, Hamani S. Dynamics of a Gel-Based Artificial Tear Film with an Emphasis on Dry Disease Treatment Applications. Gels. 2021; 7(4):215. https://doi.org/10.3390/gels7040215

Chicago/Turabian Style

Mehdaoui, Hamza, Hamid Ait Abderrahmane, Clement de Loubens, Faïçal Nait Bouda, and Sofiane Hamani. 2021. "Dynamics of a Gel-Based Artificial Tear Film with an Emphasis on Dry Disease Treatment Applications" Gels 7, no. 4: 215. https://doi.org/10.3390/gels7040215

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