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The Potential of Stimuli-Responsive Nanogels in Drug and Active Molecule Delivery for Targeted Therapy

Nutra Essential OTC, Alcobendas, Madrid 28108, Spain
Bionanoparticles Group, Facultad de Ciencias Químicas, University of the Basque Country UPV/EHU, Donostia-San Sebastián 20018, Spain
Author to whom correspondence should be addressed.
Academic Editor: Gaio Paradossi
Received: 1 March 2017 / Revised: 11 April 2017 / Accepted: 28 April 2017 / Published: 8 May 2017
(This article belongs to the Special Issue Micro- and Nanogels)
Nanogels (NGs) are currently under extensive investigation due to their unique properties, such as small particle size, high encapsulation efficiency and protection of active agents from degradation, which make them ideal candidates as drug delivery systems (DDS). Stimuli-responsive NGs are cross-linked nanoparticles (NPs), composed of polymers, natural, synthetic, or a combination thereof that can swell by absorption (uptake) of large amounts of solvent, but not dissolve due to the constituent structure of the polymeric network. NGs can undergo change from a polymeric solution (swell form) to a hard particle (collapsed form) in response to (i) physical stimuli such as temperature, ionic strength, magnetic or electric fields; (ii) chemical stimuli such as pH, ions, specific molecules or (iii) biochemical stimuli such as enzymatic substrates or affinity ligands. The interest in NGs comes from their multi-stimuli nature involving reversible phase transitions in response to changes in the external media in a faster way than macroscopic gels or hydrogels due to their nanometric size. NGs have a porous structure able to encapsulate small molecules such as drugs and genes, then releasing them by changing their volume when external stimuli are applied. View Full-Text
Keywords: stimuli-responsive nanoparticles; nanogels; drug delivery systems stimuli-responsive nanoparticles; nanogels; drug delivery systems
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MDPI and ACS Style

Vicario-de-la-Torre, M.; Forcada, J. The Potential of Stimuli-Responsive Nanogels in Drug and Active Molecule Delivery for Targeted Therapy. Gels 2017, 3, 16.

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