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Article

Candida albicans Modulates Murine and Human Beta Defensin-1 during Vaginitis

1
Laboratory of Innate Immunity to Fungal Pathogens, Department of Clinical Biochemistry, Faculty of Chemical Sciences, National University of Córdoba, Córdoba 5000, Argentina
2
Center for Research in Clinical Biochemistry and Immunology, CIBICI-CONICET, Córdoba 5000, Argentina
3
Infectious Disease Section, Hospital Privado Universitario de Córdoba, Córdoba 5000, Argentina
4
Infectology Department, Sanatorio Allende, Córdoba 5000, Argentina
5
Department of Buccal Biology, Faculty of Odontology, National University of Córdoba, Córdoba 5000, Argentina
*
Author to whom correspondence should be addressed.
Academic Editor: Richard D. Cannon
J. Fungi 2022, 8(1), 20; https://doi.org/10.3390/jof8010020
Received: 20 October 2021 / Revised: 13 December 2021 / Accepted: 14 December 2021 / Published: 28 December 2021
Vulvovaginal candidiasis (VVC) and recurrent vulvovaginal candidiasis (RVVC) are two forms of a disease caused by Candida spp. β-defensin (BD) is one of the most important families of antimicrobial peptides in the female genital tract and includes molecules that exert essential local functions as antimicrobial and PMN chemoattractant peptides. However, the information on their role during murine and human VVC and RVVC is limited. Thus, we analyzed the behavior and contribution of BD1 to the local response in a VVC mice model and the local cytokine profile and human BD1 and BD3 expression in cervicovaginal lavage from patients with VVC and RVVC. We demonstrated that, in patients with RVVC BD1, mRNA and protein expression were severely diminished and that the aspartate proteinase and lipase secreted by C. albicans are involved in that decrease. This study provides novel information about the pathogenesis of VVC and describes a highly efficient C. albicans escape strategy for perpetuating the infection; these results may contribute to the development of new or combined treatment approaches. View Full-Text
Keywords: vaginitis; vulvovaginal candidiasis; beta-defensin; antimicrobial peptides; mBD1; hBD1; fungal immunity; cytokines; Candida albicans vaginitis; vulvovaginal candidiasis; beta-defensin; antimicrobial peptides; mBD1; hBD1; fungal immunity; cytokines; Candida albicans
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MDPI and ACS Style

Miró, M.S.; Caeiro, J.P.; Rodriguez, E.; Vargas, L.; Vigezzi, C.; Icely, P.A.; Castillo, G.D.V.; Azcurra, A.I.; Abiega, C.D.; Riera, F.O.; Sotomayor, C.E. Candida albicans Modulates Murine and Human Beta Defensin-1 during Vaginitis. J. Fungi 2022, 8, 20. https://doi.org/10.3390/jof8010020

AMA Style

Miró MS, Caeiro JP, Rodriguez E, Vargas L, Vigezzi C, Icely PA, Castillo GDV, Azcurra AI, Abiega CD, Riera FO, Sotomayor CE. Candida albicans Modulates Murine and Human Beta Defensin-1 during Vaginitis. Journal of Fungi. 2022; 8(1):20. https://doi.org/10.3390/jof8010020

Chicago/Turabian Style

Miró, María S., Juan P. Caeiro, Emilse Rodriguez, Lara Vargas, Cecilia Vigezzi, Paula A. Icely, Graciela D.V. Castillo, Ana I. Azcurra, Claudio D. Abiega, Fernando O. Riera, and Claudia E. Sotomayor. 2022. "Candida albicans Modulates Murine and Human Beta Defensin-1 during Vaginitis" Journal of Fungi 8, no. 1: 20. https://doi.org/10.3390/jof8010020

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