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Article

In Vitro and In Vivo Antifungal Activity of Sorbicillinoids Produced by Trichoderma longibrachiatum

1
Center for Eco-Friendly New Materials, Korea Research Institute of Chemical Technology, Daejeon 34114, Korea
2
Department of Medicinal Chemistry and Pharmacology, University Science and Technology, Daejeon 34113, Korea
3
School of Biological Sciences, Seoul National University, Seoul 08826, Korea
*
Authors to whom correspondence should be addressed.
Academic Editor: Laurent Dufossé
J. Fungi 2021, 7(6), 428; https://doi.org/10.3390/jof7060428
Received: 29 April 2021 / Revised: 25 May 2021 / Accepted: 27 May 2021 / Published: 28 May 2021
In the search for antifungal agents from marine resources, we recently found that the culture filtrate of Trichoderma longibrachiatum SFC100166 effectively suppressed the development of tomato gray mold, rice blast, and tomato late blight. The culture filtrate was then successively extracted with ethyl acetate and n-butanol to identify the fungicidal metabolites. Consequently, a new compound, spirosorbicillinol D (1), and a new natural compound, 2′,3′-dihydro-epoxysorbicillinol (2), together with 11 known compounds (313), were obtained from the solvent extracts. The chemical structures were determined by spectroscopic analyses and comparison with literature values. The results of the in vitro antifungal assay showed that of the tested fungal pathogens, Phytophthora infestans was the fungus most sensitive to the isolated compounds, with MIC values ranging from 6.3 to 400 µg/mL, except for trichotetronine (9) and trichodimerol (10). When tomato plants were treated with the representative compounds (4, 6, 7, and 11), bisvertinolone (6) strongly reduced the development of tomato late blight disease compared to the untreated control. Taken together, our results revealed that the culture filtrate of T. longibrachiatum SFC100166 and its metabolites could be useful sources for the development of new natural agents to control late blight caused by P. infestans. View Full-Text
Keywords: Trichoderma longibrachiatum; sorbicillinoid; antifungal compound; plant pathogen Trichoderma longibrachiatum; sorbicillinoid; antifungal compound; plant pathogen
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MDPI and ACS Style

Ngo, M.T.; Nguyen, M.V.; Han, J.W.; Park, M.S.; Kim, H.; Choi, G.J. In Vitro and In Vivo Antifungal Activity of Sorbicillinoids Produced by Trichoderma longibrachiatum. J. Fungi 2021, 7, 428. https://doi.org/10.3390/jof7060428

AMA Style

Ngo MT, Nguyen MV, Han JW, Park MS, Kim H, Choi GJ. In Vitro and In Vivo Antifungal Activity of Sorbicillinoids Produced by Trichoderma longibrachiatum. Journal of Fungi. 2021; 7(6):428. https://doi.org/10.3390/jof7060428

Chicago/Turabian Style

Ngo, Men T., Minh V. Nguyen, Jae W. Han, Myung S. Park, Hun Kim, and Gyung J. Choi 2021. "In Vitro and In Vivo Antifungal Activity of Sorbicillinoids Produced by Trichoderma longibrachiatum" Journal of Fungi 7, no. 6: 428. https://doi.org/10.3390/jof7060428

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