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Review

When Uncontrolled Diabetes Mellitus and Severe COVID-19 Converge: The Perfect Storm for Mucormycosis

1
Department of Infectious Diseases, Infection Control and Employee Health, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
2
Department of Internal Medicine, The University of Texas Medical Center in Houston, Houston, TX 77093, USA
*
Author to whom correspondence should be addressed.
Academic Editor: Michaela Lackner
J. Fungi 2021, 7(4), 298; https://doi.org/10.3390/jof7040298
Received: 11 March 2021 / Revised: 10 April 2021 / Accepted: 12 April 2021 / Published: 15 April 2021
Mucormycosis (MCR) has been increasingly described in patients with coronavirus disease 2019 (COVID-19) but the epidemiological factors, presentation, diagnostic certainty, and outcome of such patients are not well described. We review the published COVID-19-associated mucormycosis (CAMCR) cases (total 41) to identify risk factors, clinical features, and outcomes. CAMCR was typically seen in patients with diabetes mellitus (DM) (94%) especially the ones with poorly controlled DM (67%) and severe or critical COVID-19 (95%). Its presentation was typical of MCR seen in diabetic patients (mostly rhino-orbital and rhino-orbital-cerebral presentation). In sharp contrast to reported COVID-associated aspergillosis (CAPA) cases, nearly all CAMCR infections were proven (93%). Treating physicians should have a high suspicion for CAMCR in patients with uncontrolled diabetes mellitus and severe COVID-19 presenting with rhino-orbital or rhino-cerebral syndromes. CAMR is the convergence of two storms, one of DM and the other of COVID-19. View Full-Text
Keywords: COVID-19; diabetes mellitus; mucormycosis COVID-19; diabetes mellitus; mucormycosis
MDPI and ACS Style

John, T.M.; Jacob, C.N.; Kontoyiannis, D.P. When Uncontrolled Diabetes Mellitus and Severe COVID-19 Converge: The Perfect Storm for Mucormycosis. J. Fungi 2021, 7, 298. https://doi.org/10.3390/jof7040298

AMA Style

John TM, Jacob CN, Kontoyiannis DP. When Uncontrolled Diabetes Mellitus and Severe COVID-19 Converge: The Perfect Storm for Mucormycosis. Journal of Fungi. 2021; 7(4):298. https://doi.org/10.3390/jof7040298

Chicago/Turabian Style

John, Teny M., Ceena N. Jacob, and Dimitrios P. Kontoyiannis 2021. "When Uncontrolled Diabetes Mellitus and Severe COVID-19 Converge: The Perfect Storm for Mucormycosis" Journal of Fungi 7, no. 4: 298. https://doi.org/10.3390/jof7040298

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