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Review

Biosensors and Diagnostics for Fungal Detection

1
Medical Research Council Centre for Medical Mycology, University of Exeter, Geoffrey Pope Building, Stocker Road, Exeter EX4 4QD, UK
2
UK National Mycology Reference Laboratory (MRL), Public Health England South-West, Science Quarter Southmead Hospital, Southmead, Bristol BS10 5NB, UK
3
Biocatalysis Centre, University of Exeter, The Henry Wellcome Building for Biocatalysis, Stocker Road, Exeter EX4 4QD, UK
4
Department of Physics and Astronomy, College of Engineering, Mathematics and Physical Sciences, University of Exeter, Exeter EX4 4QD, UK
5
Living Systems Institute, University of Exeter, Stocker Road, Exeter EX4 4QD, UK
*
Authors to whom correspondence should be addressed.
These authors made equal contributions.
J. Fungi 2020, 6(4), 349; https://doi.org/10.3390/jof6040349
Received: 19 November 2020 / Revised: 2 December 2020 / Accepted: 2 December 2020 / Published: 8 December 2020
Early detection is critical to the successful treatment of life-threatening infections caused by fungal pathogens, as late diagnosis of systemic infection almost always equates with a poor prognosis. The field of fungal diagnostics has some tests that are relatively simple, rapid to perform and are potentially suitable at the point of care. However, there are also more complex high-technology methodologies that offer new opportunities regarding the scale and precision of fungal diagnosis, but may be more limited in their portability and affordability. Future developments in this field are increasingly incorporating new technologies provided by the use of new format biosensors. This overview provides a critical review of current fungal diagnostics and the development of new biophysical technologies that are being applied for selective new sensitive fungal biosensors to augment traditional diagnostic methodologies. View Full-Text
Keywords: biosensors; diagnostics; medical mycology; fungal biomarker; point-of-care devices; immobilization biosensors; diagnostics; medical mycology; fungal biomarker; point-of-care devices; immobilization
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MDPI and ACS Style

K. Hussain, K.; Malavia, D.; M. Johnson, E.; Littlechild, J.; Winlove, C.P.; Vollmer, F.; Gow, N.A.R. Biosensors and Diagnostics for Fungal Detection. J. Fungi 2020, 6, 349. https://doi.org/10.3390/jof6040349

AMA Style

K. Hussain K, Malavia D, M. Johnson E, Littlechild J, Winlove CP, Vollmer F, Gow NAR. Biosensors and Diagnostics for Fungal Detection. Journal of Fungi. 2020; 6(4):349. https://doi.org/10.3390/jof6040349

Chicago/Turabian Style

K. Hussain, Khalil, Dhara Malavia, Elizabeth M. Johnson, Jennifer Littlechild, C. P. Winlove, Frank Vollmer, and Neil A.R. Gow. 2020. "Biosensors and Diagnostics for Fungal Detection" Journal of Fungi 6, no. 4: 349. https://doi.org/10.3390/jof6040349

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