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Article

In Vitro and In Vivo Inhibitory Activity of Limonene against Different Isolates of Candida spp.

1
Studies in Translational Microbiology and Emerging Diseases Research Group (MICROS), School of Medicine and Health Sciences, Universidad del Rosario, Bogotá D.C 111221, Colombia
2
Department of Microbiology, Biomedical Sciences Institute, University of São Paulo (USP), São Paulo 05508-060, Brazil
3
Núcleo Integrado de Biotecnologia, Universidade de Mogi das Cruzes (UMC), Mogi das Cruzes-SP 08780-911, Brazil
4
Centro de Ciências Naturais e Humanas, Universidade Federal do ABC (UFABC), São Bernardo do Campo 09210-580, Brazil
5
Laboratory of Medical Mycology, Institute of Tropical Medicine of São Paulo-LIM53/Medical School, University of São Paulo (USP), São Paulo 05403-000, Brazil
*
Author to whom correspondence should be addressed.
J. Fungi 2020, 6(3), 183; https://doi.org/10.3390/jof6030183
Received: 4 June 2020 / Revised: 3 August 2020 / Accepted: 10 August 2020 / Published: 22 September 2020
(This article belongs to the Special Issue Systemic and Emerging Mycoses)
Commensal yeast from the genus Candida is part of the healthy human microbiota. In some cases, Candida spp. dysbiosis can result in candidiasis, the symptoms of which may vary from mild localized rashes to severe disseminated infections. The most prevalent treatments against candidiasis involve fluconazole, itraconazole, miconazole, and caspofungin. Moreover, amphotericin B associated with prolonged azole administration is utilized to control severe cases. Currently, numerous guidelines recommend echinocandins to treat invasive candidiasis. However, resistance to these antifungal drugs has increased dramatically over recent years. Considering this situation, new therapeutic alternatives should be studied to control candidiasis, which has become a major medical concern. Limonene belongs to the group of terpene molecules, known for their pharmacological properties. In this study, we evaluated in vitro the limonene concentration capable of inhibiting the growth of yeast from the genus Candida susceptible or resistant to antifungal drugs and its capacity to induce fungal damage. In addition, intravaginal fungal infection assays using a murine model infected by Candida albicans were carried out and the fungal burden, histopathology, and scanning electron microscopy were evaluated. All of our results suggest that limonene may play a protective role against the infection process by yeast from the genus Candida. View Full-Text
Keywords: Candidiasis; Candida spp.; limonene; treatment; intravaginal infection Candidiasis; Candida spp.; limonene; treatment; intravaginal infection
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MDPI and ACS Style

Muñoz, J.E.; Rossi, D.C.P.; Jabes, D.L.; Barbosa, D.A.; Cunha, F.F.M.; Nunes, L.R.; Arruda, D.C.; Pelleschi Taborda, C. In Vitro and In Vivo Inhibitory Activity of Limonene against Different Isolates of Candida spp. J. Fungi 2020, 6, 183. https://doi.org/10.3390/jof6030183

AMA Style

Muñoz JE, Rossi DCP, Jabes DL, Barbosa DA, Cunha FFM, Nunes LR, Arruda DC, Pelleschi Taborda C. In Vitro and In Vivo Inhibitory Activity of Limonene against Different Isolates of Candida spp. Journal of Fungi. 2020; 6(3):183. https://doi.org/10.3390/jof6030183

Chicago/Turabian Style

Muñoz, Julián E., Diego C.P. Rossi, Daniela L. Jabes, David A. Barbosa, Fernanda F.M. Cunha, Luiz R. Nunes, Denise C. Arruda, and Carlos Pelleschi Taborda. 2020. "In Vitro and In Vivo Inhibitory Activity of Limonene against Different Isolates of Candida spp." Journal of Fungi 6, no. 3: 183. https://doi.org/10.3390/jof6030183

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