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J. Fungi 2018, 4(4), 117; https://doi.org/10.3390/jof4040117

Nebulised N-Acetylcysteine for Unresponsive Bronchial Obstruction in Allergic Brochopulmonary Aspergillosis: A Case Series and Review of the Literature

1
Department of Internal Medicine, College of Medical Sciences, University of Calabar, Calabar, Cross River State P.M.B. 1115, Nigeria
2
The National Aspergillosis Centre, 2nd Floor Education and Research Centre, Wythenshawe Hospital, Southmoor Road, Manchester M23 9LT, UK
3
Faculty of Biology, Medicine and Health, The University of Manchester, and Manchester Academic Health Science Centre, Oxford Rd, Manchester M13 9PL, UK
*
Author to whom correspondence should be addressed.
Received: 5 September 2018 / Revised: 2 October 2018 / Accepted: 8 October 2018 / Published: 15 October 2018
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Abstract

Many chronic lung diseases are characterized by the hypersecretion of mucus. In these conditions, the administration of mucoactive agents is often indicated as adjuvant therapy. N-acetylcysteine (NAC) is a typical example of a mucolytic agent. A retrospective review of patients with pulmonary aspergillosis treated at the National Aspergillosis Centre in Manchester, United Kingdom, with NAC between November 2015 and November 2017 was carried out. Six Caucasians with Aspergillus lung disease received NAC to facilitate clearance of their viscid bronchial mucus secretions. One patient developed immediate bronchospasm on the first dose and could not be treated. Of the remainder, two (33%) derived benefit, with increased expectoration and reduced symptoms. Continued response was sustained over 6–7 months, without any apparent toxicity. In addition, a systematic review of the literature is provided to analyze the utility of NAC in the management of respiratory conditions which have unresponsive bronchial obstruction as a feature. View Full-Text
Keywords: N-acetylcysteine; mucolytic; allergic bronchopulmonary aspergillosis N-acetylcysteine; mucolytic; allergic bronchopulmonary aspergillosis
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Otu, A.; Langridge, P.; Denning, D.W. Nebulised N-Acetylcysteine for Unresponsive Bronchial Obstruction in Allergic Brochopulmonary Aspergillosis: A Case Series and Review of the Literature. J. Fungi 2018, 4, 117.

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