Reply to Cosio et al. Glycation of Nail Proteins as a Risk Factor for Onychomycosis. Comment on “Gupta et al. Diabetic Foot and Fungal Infections: Etiology and Management from a Dermatologic Perspective. J. Fungi 2024, 10, 577”

Gupta, Aditya K.; Shemer, Avner; Economopoulos, Vasiliki; Talukder, Mesbah

doi:10.3390/jof11010047

Open AccessReply

Reply to Cosio et al. Glycation of Nail Proteins as a Risk Factor for Onychomycosis. Comment on “Gupta et al. Diabetic Foot and Fungal Infections: Etiology and Management from a Dermatologic Perspective. J. Fungi 2024, 10, 577”

by

Aditya K. Gupta

^1,2,*

,

Avner Shemer

^3,4,

Vasiliki Economopoulos

^2,5 and

Mesbah Talukder

^2,6

¹

Division of Dermatology, Department of Medicine, Temerty Faculty of Medicine, University of Toronto, Toronto, ON M5S 3H2, Canada

²

Mediprobe Research Inc., London, ON N5X 2P1, Canada

³

Department of Dermatology, Sheba Medical Center, Tel-Hashomer, Ramat-Gan 52621, Israel

⁴

Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv 6997801, Israel

⁵

Department of Medical Biophysics, Schulich School of Medicine and Dentistry, Western University, London, ON N6A 3K7, Canada

⁶

School of Pharmacy, BRAC University, Dhaka 1212, Bangladesh

^*

Author to whom correspondence should be addressed.

J. Fungi 2025, 11(1), 47; https://doi.org/10.3390/jof11010047

Submission received: 5 December 2024 / Accepted: 2 January 2025 / Published: 8 January 2025

Download Versions Notes

We find the comment on the article titled “Diabetic Foot and Fungal Infections: Etiology and Management from a Dermatologic Perspective” informative and wish to thank the authors for their added insight on this complex topic [1,2]. We agree that advanced glycation products formed within the diabetic patient may play a role directly in the development of onychomycosis. Understandably, there are multiple mechanisms at play for the increased risk of infection and complications in this patient population. The immunological pathways described are only one part of a much larger picture. Further knowledge on the interplay of these pathways, as well as any additional mechanisms, will be of the utmost importance to reducing the burden of onychomycosis in diabetic patients.

Conflicts of Interest

Authors Aditya K. Gupta, Vasiliki Economopoulos and Mesbah Talukder were employed by the company Mediprobe Research Inc. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

References

Gupta, A.K.; Shemer, A.; Economopoulos, V.; Talukder, M. Diabetic Foot and Fungal Infections: Etiology and Management from a Dermatologic Perspective. J. Fungi 2024, 10, 577. [Google Scholar] [CrossRef] [PubMed]
Cosio, T.; Valsecchi, I.; Gaziano, R.; Campione, E.; Botterel, F. Glycation of Nail Proteins as a Risk Factor for Onychomycosis. Comment on Gupta et al. Diabetic Foot and Fungal Infections: Etiology and Management from a Dermatologic Perspective. J. Fungi 2024, 10, 577. J. Fungi 2025, 11, 46. [Google Scholar] [CrossRef]

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© 2025 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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MDPI and ACS Style

Gupta, A.K.; Shemer, A.; Economopoulos, V.; Talukder, M. Reply to Cosio et al. Glycation of Nail Proteins as a Risk Factor for Onychomycosis. Comment on “Gupta et al. Diabetic Foot and Fungal Infections: Etiology and Management from a Dermatologic Perspective. J. Fungi 2024, 10, 577”. J. Fungi 2025, 11, 47. https://doi.org/10.3390/jof11010047

AMA Style

Gupta AK, Shemer A, Economopoulos V, Talukder M. Reply to Cosio et al. Glycation of Nail Proteins as a Risk Factor for Onychomycosis. Comment on “Gupta et al. Diabetic Foot and Fungal Infections: Etiology and Management from a Dermatologic Perspective. J. Fungi 2024, 10, 577”. Journal of Fungi. 2025; 11(1):47. https://doi.org/10.3390/jof11010047

Chicago/Turabian Style

Gupta, Aditya K., Avner Shemer, Vasiliki Economopoulos, and Mesbah Talukder. 2025. "Reply to Cosio et al. Glycation of Nail Proteins as a Risk Factor for Onychomycosis. Comment on “Gupta et al. Diabetic Foot and Fungal Infections: Etiology and Management from a Dermatologic Perspective. J. Fungi 2024, 10, 577”" Journal of Fungi 11, no. 1: 47. https://doi.org/10.3390/jof11010047

APA Style

Gupta, A. K., Shemer, A., Economopoulos, V., & Talukder, M. (2025). Reply to Cosio et al. Glycation of Nail Proteins as a Risk Factor for Onychomycosis. Comment on “Gupta et al. Diabetic Foot and Fungal Infections: Etiology and Management from a Dermatologic Perspective. J. Fungi 2024, 10, 577”. Journal of Fungi, 11(1), 47. https://doi.org/10.3390/jof11010047

Note that from the first issue of 2016, this journal uses article numbers instead of page numbers. See further details here.

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Reply to Cosio et al. Glycation of Nail Proteins as a Risk Factor for Onychomycosis. Comment on “Gupta et al. Diabetic Foot and Fungal Infections: Etiology and Management from a Dermatologic Perspective. J. Fungi 2024, 10, 577”

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