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Volume 10
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10.3390/jof10040285
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Article

Enhancing Candida auris Surveillance in High-Risk Settings by Implementing a High-Throughput Molecular Assay on the Hologic Fusion Open Access Platform

by
Filipe M. Cerqueira
,
Jennifer Bertsch
,
Mary Ann DeMaet
,
Teresa York
,
April McDougal
,
Janak A. Patel
and
Ping Ren
*
Department of Pathology, University of Texas Medical Branch, Galveston, TX 77555, USA
*
Author to whom correspondence should be addressed.
J. Fungi 2024, 10(4), 285; https://doi.org/10.3390/jof10040285
Submission received: 6 February 2024 / Revised: 18 March 2024 / Accepted: 10 April 2024 / Published: 12 April 2024
(This article belongs to the Special Issue Infection Prevention and Control of Fungal Infections)
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Abstract

Candida auris, a resilient pathogenic yeast with frequent multidrug resistance, presents a persistent challenge in healthcare settings. The timely identification of C. auris is crucial for infection control and prevention, especially in facilities facing unique hurdles, such as our institution, which serves four major hospitals and approximately 80% of the Texas inmate population. Understaffing, communal living, and financial constraints exacerbate infection control issues. To address common staff shortages, streamline testing services, and enhance testing efficiency, there was a pressing need for rapid and high-throughput detection of C. auris. This study presents the validation and utility of an assay implemented on the Hologic Fusion Open Access platform using samples collected from high-risk patients’ axilla and groin areas, as well as environmental swab samples from patient rooms. Our assay complemented efforts to control C. auris outbreaks within our healthcare system, providing valuable insights into its presence within surveillance samples. This assay demonstrated the value of high-throughput molecular detection platforms in challenging healthcare environments by aiding infection preventionists in containing the spread of C. auris and preventing nosocomial infections. Our research contributes essential data on the suitability and performance of the Hologic Fusion Open Access platform for C. auris detection. These findings hold significant implications for enhancing surveillance and control measures in high-risk settings, making a significant impact on the field of infection control and prevention.
Keywords: Candida auris; surveillance; high-throughput; infection control Candida auris; surveillance; high-throughput; infection control

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MDPI and ACS Style

Cerqueira, F.M.; Bertsch, J.; DeMaet, M.A.; York, T.; McDougal, A.; Patel, J.A.; Ren, P. Enhancing Candida auris Surveillance in High-Risk Settings by Implementing a High-Throughput Molecular Assay on the Hologic Fusion Open Access Platform. J. Fungi 2024, 10, 285. https://doi.org/10.3390/jof10040285

AMA Style

Cerqueira FM, Bertsch J, DeMaet MA, York T, McDougal A, Patel JA, Ren P. Enhancing Candida auris Surveillance in High-Risk Settings by Implementing a High-Throughput Molecular Assay on the Hologic Fusion Open Access Platform. Journal of Fungi. 2024; 10(4):285. https://doi.org/10.3390/jof10040285

Chicago/Turabian Style

Cerqueira, Filipe M., Jennifer Bertsch, Mary Ann DeMaet, Teresa York, April McDougal, Janak A. Patel, and Ping Ren. 2024. "Enhancing Candida auris Surveillance in High-Risk Settings by Implementing a High-Throughput Molecular Assay on the Hologic Fusion Open Access Platform" Journal of Fungi 10, no. 4: 285. https://doi.org/10.3390/jof10040285

APA Style

Cerqueira, F. M., Bertsch, J., DeMaet, M. A., York, T., McDougal, A., Patel, J. A., & Ren, P. (2024). Enhancing Candida auris Surveillance in High-Risk Settings by Implementing a High-Throughput Molecular Assay on the Hologic Fusion Open Access Platform. Journal of Fungi, 10(4), 285. https://doi.org/10.3390/jof10040285

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