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Cryptococcus: Shedding New Light on an Inveterate Yeast

by Ghady Haidar 1 and Nina Singh 2,*
Division of Infectious Diseases, Department of Medicine, University of Pittsburgh Medical Center, Pittsburgh, PA 15240, USA
VA Pittsburgh Healthcare System, Infectious Diseases Section, and University of Pittsburgh, Pittsburgh, PA 15240, USA
Author to whom correspondence should be addressed.
Academic Editor: Shmuel Shoham
J. Fungi 2015, 1(2), 115-129;
Received: 7 May 2015 / Revised: 1 July 2015 / Accepted: 8 July 2015 / Published: 14 July 2015
(This article belongs to the Special Issue Fungal Infections in Transplant Recipients)
Cryptococcus has emerged as a significant pathogen in immunocompromised patients. While the diagnostic testing and the antifungal treatment of cryptococcal infections have become firmly established in clinical practice, new developments and areas of ambiguity merit further consideration. These include the potential for donor transmission of Cryptococcus; cirrhosis-associated cryptococcosis, particularly during transplant candidacy; the utility of serum cryptococcal antigen testing of asymptomatic individuals in high-prevalence, poor-resource areas; pathogenesis and treatment of the immune reconstitution syndrome, specifically in relation to antiretroviral therapy and immunosuppressive medications; and new challenges posed by the emerging species of Cryptococcus gatti. In this article, we summarize the literature pertaining to these topics, focusing on recent progress. View Full-Text
Keywords: Cryptococcus; cirrhosis; immune reconstitution syndrome; transplant; human immunodeficiency virus Cryptococcus; cirrhosis; immune reconstitution syndrome; transplant; human immunodeficiency virus
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Haidar, G.; Singh, N. Cryptococcus: Shedding New Light on an Inveterate Yeast. J. Fungi 2015, 1, 115-129.

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