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Open AccessArticle

Are Chronic Rhinosinusitis and Paranasal Sinus Pneumatization Related?

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Department of Otolaryngology-Head and Neck Surgery, Tulane University School of Medicine, New Orleans, LA 70112, USA
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Department of Otorhinolaryngology, Ochsner Clinic Foundation, New Orleans, LA 70121, USA
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Ochsner Clinical School, University of Queensland School of Medicine, New Orleans, LA 70121, USA
*
Author to whom correspondence should be addressed.
Academic Editor: César Picado
Sinusitis 2016, 1(1), 92-98; https://doi.org/10.3390/sinusitis1010092
Received: 8 October 2016 / Revised: 11 November 2016 / Accepted: 21 November 2016 / Published: 28 November 2016
The relationship between paranasal sinus pneumatization and chronic rhinosinusitis (CRS) without cystic fibrosis is not well understood. Previous investigations have confirmed sinus hypoplasia in cystic fibrosis (CF) patients. This study compares paranasal sinus pneumatization of CRS patients to unaffected controls to determine if there is an analogous effect to that seen in CF. 591 sinus computed tomography (CT) scans, comprised of 303 adolescents (age 13–18) and 288 adults (age > 18), were analyzed for Lund-MacKay and Assessment of Pneumatization of the Paranasal Sinuses (APPS) scores. The APPS score is validated for measuring the extent of sinus pneumatization. A diagnosis of CRS and CRS phenotype was determined from the medical record. The mean APPS score for patients with a diagnosis of CRS was 10.61 (n = 111) compared to 9.62 (n = 448) for unaffected controls (p = 0.001). This was significant in adult (p = 0.021) and adolescent subgroups (p = 0.035). Sinus pneumatization did not differ according to CRS phenotype (p = 0.699). This suggests that there is not analogous anatomical sinus variation between CRS and CF, and that the mechanisms underlying sinus hypoplasia in CF may not be universal in patients with other types of sinus inflammation. View Full-Text
Keywords: pneumatization; paranasal sinuses; computed tomography; chronic rhinosinusitis; cystic fibrosis pneumatization; paranasal sinuses; computed tomography; chronic rhinosinusitis; cystic fibrosis
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Marino, M.J.; Riley, C.A.; Wu, E.L.; Weinstein, J.E.; McCoul, E.D. Are Chronic Rhinosinusitis and Paranasal Sinus Pneumatization Related? Sinusitis 2016, 1, 92-98.

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