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Cauterization as a Simple Method for Regeneration Studies in the Zebrafish Heart
Review

Unlocking the Secrets of the Regenerating Fish Heart: Comparing Regenerative Models to Shed Light on Successful Regeneration

Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford OX1 3PT, UK
*
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
J. Cardiovasc. Dev. Dis. 2021, 8(1), 4; https://doi.org/10.3390/jcdd8010004
Received: 2 December 2020 / Revised: 11 January 2021 / Accepted: 12 January 2021 / Published: 16 January 2021
(This article belongs to the Special Issue Zebrafish Heart Development, Regeneration, and Disease Modelling)
The adult human heart cannot repair itself after injury and, instead, forms a permanent fibrotic scar that impairs cardiac function and can lead to incurable heart failure. The zebrafish, amongst other organisms, has been extensively studied for its innate capacity to repair its heart after injury. Understanding the signals that govern successful regeneration in models such as the zebrafish will lead to the development of effective therapies that can stimulate endogenous repair in humans. To date, many studies have investigated cardiac regeneration using a reverse genetics candidate gene approach. However, this approach is limited in its ability to unbiasedly identify novel genes and signalling pathways that are essential to successful regeneration. In contrast, drawing comparisons between different models of regeneration enables unbiased screens to be performed, identifying signals that have not previously been linked to regeneration. Here, we will review in detail what has been learnt from the comparative approach, highlighting the techniques used and how these studies have influenced the field. We will also discuss what further comparisons would enhance our knowledge of successful regeneration and scarring. Finally, we focus on the Astyanax mexicanus, an intraspecies comparative fish model that holds great promise for revealing the secrets of the regenerating heart. View Full-Text
Keywords: heart; regeneration; scarring; zebrafish; teleost fish; Astyanax mexicanus; comparative approach; interorgan heart; regeneration; scarring; zebrafish; teleost fish; Astyanax mexicanus; comparative approach; interorgan
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MDPI and ACS Style

Potts, H.G.; Stockdale, W.T.; Mommersteeg, M.T.M. Unlocking the Secrets of the Regenerating Fish Heart: Comparing Regenerative Models to Shed Light on Successful Regeneration. J. Cardiovasc. Dev. Dis. 2021, 8, 4. https://doi.org/10.3390/jcdd8010004

AMA Style

Potts HG, Stockdale WT, Mommersteeg MTM. Unlocking the Secrets of the Regenerating Fish Heart: Comparing Regenerative Models to Shed Light on Successful Regeneration. Journal of Cardiovascular Development and Disease. 2021; 8(1):4. https://doi.org/10.3390/jcdd8010004

Chicago/Turabian Style

Potts, Helen G., William T. Stockdale, and Mathilda T.M. Mommersteeg. 2021. "Unlocking the Secrets of the Regenerating Fish Heart: Comparing Regenerative Models to Shed Light on Successful Regeneration" Journal of Cardiovascular Development and Disease 8, no. 1: 4. https://doi.org/10.3390/jcdd8010004

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