rs2569190A>G in CD14 is Independently Associated with Hypercholesterolemia: A Brief Report
Abstract
1. Introduction
2. Materials and Methods
2.1. Study Population
2.2. Clinical and Biological Data Collection
2.3. Statistical Analyses
3. Results
3.1. Characteristics of the Studied Participants
3.2. Association of rs2569190A>G in CD14 with Hypercholesterolemia
4. Discussion
5. Conclusions
Author Contributions
Funding
Conflicts of Interest
References
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Characteristics | Participants (n = 460) |
---|---|
Age | 40.60 ± 14.16 |
Gender n (%) | |
Male | 168 (36.5) |
Female | 292 (63.5) |
Smoking status n (%) | |
Nonsmoker | 332 (72.2) |
Past smoker | 6 (1.3) |
Current smoker | 122 (26.5) |
Marital Status n (%) | |
Single | 121 (26.3) |
Married | 321 (69.8) |
Divorced | 18 (3.9) |
Physical Activity n (%) | |
<1 per week | 345 (75.0) |
1 per week | 52 (11.3) |
≥2 per week | 63 (13.7) |
Characteristics | Participants (n = 460) |
---|---|
BMI (Kg/m2) | 25.71 ± 4.98 |
Total cholesterol (mg/dL) | 181.41 ± 40.94 |
High total cholesterol levels n (%) | 351 (76.3) |
LDL-C (mg/dL) | 117.39 ± 33.52 |
High LDL-C levels n (%) | 347 (75.4) |
HDL-C (mg/dL) | 45.53 ± 14.61 |
Low HDL-C levels n (%) | 270 (58.7) |
Triglycerides (mg/dL) | 145.96 ± 124.34 |
High triglycerides levels n (%) | 174 (37.8) |
SBP (mmHg) | 132.07 ± 15.89 |
DBP (mmHg) | 67.82 ± 9.12 |
Hypertension n (%) | 255 (55.4) |
MAF of rs2569190G in CD14 | 0.41 |
AA n (%) | 158 (34.3) |
GA n (%) | 224 (48.7) |
GG n (%) | 78 (17.0) |
Variables | Total Cholesterol | LDL-Cholesterol | HDL-Cholesterol | Hypertension | ||||
---|---|---|---|---|---|---|---|---|
OR (95% C.I.) | p | OR (95% C.I.) | p | OR (95% C.I.) | p | OR (95% C.I.) | p | |
rs2569190 AA | 1 | 1 | 1 | 1 | ||||
GA | 0.97 (0.57–1.63) | 0.900 | 0.98 (0.59–1.64) | 0.939 | 0.89 (0.56–1.43) | 0.636 | 0.89 (0.56–1.40) | 0.607 |
GG | 3.04 (1.23–7.48) | 0.016 | 3.83 (1.48–9.88) | 0.006 | 0.36 (0.19–0.67) | 0.001 | 0.67 (0.36–1.24) | 0.203 |
rs2569190 AA and GA | 1 | 1 | 1 | 1 | ||||
GG | 3.10 (1.33–7.23) | 0.009 | 3.87 (1.58–9.51) | 0.003 | 0.38 (0.22–0.67) | 0.001 | 0.72 (0.41–1.25) | 0.186 |
Age | ||||||||
<40 | 1 | 1 | 1 | 1 | ||||
≥40 | 2.06 (1.18–3.59) | 0.011 | 2.22 (1.28–3.86) | 0.004 | 1.58 (0.99–2.51) | 0.056 | 0.73 (0.47–1.16) | 0.181 |
Gender | ||||||||
Male | 1 | 1 | 1 | 1 | ||||
Female | 1.21 (0.69–2.12) | 0.503 | 0.98 (0.56–1.71) | 0.931 | 1.17 (0.72–1.90) | 0.523 | 0.46 (0.29–0.75) | 0.002 |
BMI | ||||||||
<25 | 1 | 1 | 1 | 1 | ||||
25–29.9 | 0.63 (0.34–1.15) | 0.132 | 0.51 (0.28–0.93) | 0.027 | 2.64 (1.50–4.65) | 0.001 | 0.74 (0.44–1.26) | 0.267 |
≥30 | 1.15 (0.56–2.34) | 0.704 | 1.19 (0.58–2.43) | 0.638 | 1.02 (0.57–1.80) | 0.956 | 1.40 (0.78–2.51) | 0.256 |
Marital status | ||||||||
Single | 1 | 1 | 1 | 1 | ||||
Married | 0.60 (0.31–1.15) | 0.124 | 0.83 (0.44–1.56) | 0.566 | 0.75 (0.43–1.30) | 0.306 | 0.70 (0.41–1.22) | 0.206 |
Divorced | 0.76 (0.21–2.76) | 0.681 | 1.06 (0.29–3.83) | 0.935 | 2.06 (0.57–7.47) | 0.271 | 0.33 (0.10–1.07) | 0.065 |
Smoking status | ||||||||
Non smoker | 1 | 1 | 1 | 1 | ||||
Past smoker | 0.71 (0.11–4.62) | 0.720 | 0.72 (0.11–4.72) | 0.735 | 0.63 (0.11–3.67) | 0.607 | 0.17 (0.03–1.13) | 0.067 |
Current smoker | 2.18 (1.12–4.21) | 0.021 | 1.88 (0.99–3.53) | 0.050 | 0.41 (0.24–0.68) | 0.001 | 0.74 (0.45–1.22) | 0.233 |
Physical activity | ||||||||
<1 per week | 1 | 1 | 1 | 1 | ||||
1 per week | 0.27 (0.13–0.58) | 0.001 | 0.28 (0.13–0.60) | 0.001 | 0.40 (0.19–0.85) | 0.017 | 0.99 (0.48–2.04) | 0.971 |
≥2 per week | 0.69 (0.33–1.41) | 0.304 | 1.27 (0.59–2.74) | 0.536 | 0.57 (0.30–1.11) | 0.100 | 0.90 (0.48–1.70) | 0.752 |
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Salami, A.; Costanian, C.; El Shamieh, S. rs2569190A>G in CD14 is Independently Associated with Hypercholesterolemia: A Brief Report. J. Cardiovasc. Dev. Dis. 2019, 6, 37. https://doi.org/10.3390/jcdd6040037
Salami A, Costanian C, El Shamieh S. rs2569190A>G in CD14 is Independently Associated with Hypercholesterolemia: A Brief Report. Journal of Cardiovascular Development and Disease. 2019; 6(4):37. https://doi.org/10.3390/jcdd6040037
Chicago/Turabian StyleSalami, Ali, Christy Costanian, and Said El Shamieh. 2019. "rs2569190A>G in CD14 is Independently Associated with Hypercholesterolemia: A Brief Report" Journal of Cardiovascular Development and Disease 6, no. 4: 37. https://doi.org/10.3390/jcdd6040037
APA StyleSalami, A., Costanian, C., & El Shamieh, S. (2019). rs2569190A>G in CD14 is Independently Associated with Hypercholesterolemia: A Brief Report. Journal of Cardiovascular Development and Disease, 6(4), 37. https://doi.org/10.3390/jcdd6040037