rs2569190A>G in CD14 is Independently Associated with Hypercholesterolemia: A Brief Report
Rammal Hassan Rammal Research Laboratory, Physio-toxicity (PhyTox) Research Group, Lebanese University, Faculty of Sciences (V), Nabatieh 1700, Lebanon
Faculty of Medicine, University of Ottawa, Ottawa 61350, ON K1G 5Z3, Canada
School of Medicine, Lebanese American University, Beirut 1102 2801, Lebanon
Department of Medical Laboratory Technology, Faculty of Health Sciences, Beirut Arab University, Beirut 115020, Lebanon
Author to whom correspondence should be addressed.
Academic Editor: Maurice Van den Hoff
J. Cardiovasc. Dev. Dis. 2019, 6(4), 37; https://doi.org/10.3390/jcdd6040037
Received: 5 September 2019 / Revised: 27 October 2019 / Accepted: 28 October 2019 / Published: 30 October 2019
(This article belongs to the Special Issue Nutrition, Genetics, and Cardiovascular Disease)
Many studies have assessed the implication of cluster of differentiation 14 (CD14) molecules and its single nucleotide polymorphism rs2569190A>G with different complex diseases, such as diabetes and cardiovascular diseases (CVDs). In this study, we investigated the association of rs2569190A>G in CD14 with cardiovascular disease risk factors (hypercholesterolemia and hypertension) in 460 individuals from the general Lebanese population (Middle Eastern multiethnic population). Using a multiple logistic regression model adjusted for six covariates (under additive and recessive assumptions), we found that the G allele of rs2569190 in CD14 was associated with increased levels of total cholesterol (OR = 3.10, p = 0.009), low-density lipoprotein cholesterol (OR = 3.87, p = 0.003), and decreased levels of high-density lipoprotein cholesterol (OR = 0.38, p = 0.001). In contrast, no significant relationship was found with hypertension. Thus, we concluded that rs2569190G in CD14 is associated with a higher risk of developing hypercholesterolemia.