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The Development of Compartmentation of cAMP Signaling in Cardiomyocytes: The Role of T-Tubules and Caveolae Microdomains
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Functional Significance of the Adcy10-Dependent Intracellular cAMP Compartments

by Sofya Pozdniakova 1,2,* and Yury Ladilov 1,2
Institute of Gender in Medicine, Center for Cardiovascular Research, Charite, 10115 Berlin, Germany
DZHK (German Center for Cardiovascular Research), Berlin Partner Site, 10115 Berlin, Germany
Author to whom correspondence should be addressed.
J. Cardiovasc. Dev. Dis. 2018, 5(2), 29;
Received: 5 March 2018 / Revised: 4 May 2018 / Accepted: 9 May 2018 / Published: 11 May 2018
(This article belongs to the Special Issue Cyclic Nucleotide Signaling and the Cardiovascular System)
Mounting evidence confirms the compartmentalized structure of evolutionarily conserved 3′–5′-cyclic adenosine monophosphate (cAMP) signaling, which allows for simultaneous participation in a wide variety of physiological functions and ensures specificity, selectivity and signal strength. One important player in cAMP signaling is soluble adenylyl cyclase (sAC). The intracellular localization of sAC allows for the formation of unique intracellular cAMP microdomains that control various physiological and pathological processes. This review is focused on the functional role of sAC-produced cAMP. In particular, we examine the role of sAC-cAMP in different cellular compartments, such as cytosol, nucleus and mitochondria. View Full-Text
Keywords: adcy10; cAMP; phosphodiesterase; compartmentalization adcy10; cAMP; phosphodiesterase; compartmentalization
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Pozdniakova, S.; Ladilov, Y. Functional Significance of the Adcy10-Dependent Intracellular cAMP Compartments. J. Cardiovasc. Dev. Dis. 2018, 5, 29.

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