The Clock Drawing Test: A Valid Screening Instrument for Dementia Detection in Low-Educated Patients?
Abstract
1. Background
2. Materials and Methods
2.1. Data Source and Setting
2.2. Cohorts
2.3. Instruments
2.4. Data Analysis
3. Results
3.1. Baseline Characteristics
| Clinical Diagnosis | ||||||
|---|---|---|---|---|---|---|
| No Cognitive Impairment | MCI 5 | Dementia | Other Diagnosis | Total | p | |
| N | 130 | 171 | 180 | 22 | 503 | |
| Gender, male (N, %) | 53 (41%) | 64 (37%) | 79 (44%) | 9 (41%) | 205 (41%) | X2 (3) = 1.51; p = 0.68 |
| Age (M, SD) | 77 (8.3) | 80 (8.0) | 82 (7.3) | 78 (9.0) | 80 (8.1) | K-W 6 (3) = 26.3; p ≤ 0.001 |
| Education | ||||||
| No education (N, %) | 5 (4%) | 2 (1%) | 4 (2%) | 0 (0%) | 11 (2%) | X2 (9) = 28.0; p ≤ 0.001 |
| Low education 1 (N, %) | 29 (22%) | 31 (38%) | 69 (14%) | 3 (14%) | 132 (26%) | |
| Middle education 2 (N, %) | 69 (53%) | 103 (60%) | 83 (46%) | 12 (55%) | 267 (53%) | |
| High education 3 (N, %) | 27 (21%) | 35 (20%) | 24 (13%) | 7 (32%) | 93 (18%) | |
| Ethnicity | ||||||
| Dutch (N, %) | 85 (66%) | 129 (75%) | 128 (72%) | 16 (76%) | 358 (72%) | X2 (12) = 9.9; p = 0.62 |
| Turkish (N, %) | 8 (6%) | 3 (2%) | 8 (4%) | 0 (0%) | 19 (4%) | |
| Moroccan (N, %) | 5 (4%) | 5 (3%) | 5 (3%) | 0 (0%) | 15 (3%) | |
| Surinamese/Hindustani (N, %) | 2 (%) | 0 (0%) | 2 (1%) | 0 (0%) | 4 (1%) | |
| Other (N, %) | 29 (22%) | 34 (20%) | 35 (20%) | 5 (24%) | 103 (21%) | |
| MMSE 4 (M, SD) | 26 (3.8) | 24 (3.5) | 19 (5.6) | 23 (5.8) | 23 (5.3) | K-W 6 (3) = 128; p ≤ 0.001 |
| CDT score 7 (M, SD) | 5.1 (1.41) | 4.3 (1.71) | 3.2 (1.94) | 3.7 (1.88) | 4.1 (1.88) | |
| Cut-off < 3 (N; %) 8 | 9 (7%) | 26 (15%) | 69 (38%) | 7 (32%) | 111 (22%) | X2 (3) = 51.0; p ≤ 0.001 |
| Cut-off < 4 (N; %) 9 | 22 (17%) | 56 (33%) | 105 (58%) | 11 (50%) | 194 (39%) | X2 (3) = 59.0; p ≤ 0.001 |

| N | Sensitivity% (95% CI 1) | Specificity% (95% CI) | Youden Index 2 | PPV 3 (95% CI) | NPV 4 (95% CI) | LR+ 5 (95% CI) | LR− 6 (95% CI) | |
|---|---|---|---|---|---|---|---|---|
| Cutoff < 3 | ||||||||
| Total | 481 | 38% (31–46%) | 88% (84–92%) | 0.26 | 66% (58–74%) | 71% (68–73%) | 3.30 (2.29–4.74) | 0.70 (0.62–0.79) |
| No education | 11 | 25% (0.63–81%) | 71% (29–96%) | −0.04 | 33% (6–80%) | 63% (44–78%) | 0.88 (0.11–6.88) | 1.05 (0.50–2.19) |
| Low education | 129 | 46% (34–59%) | 87% (75–94%) | 0.33 | 80% (67–89%) | 58% (52–64%) | 3.48 (1.74–6.96) | 0.62 (0.49–0.79) |
| Middle education | 255 | 34% (24–45%) | 88% (82–92%) | 0.22 | 57% (45–69%) | 73% (70–76%) | 2.76 (1.67–4.56) | 0.75 (0.64–0.89) |
| High education | 86 | 33% (16–55%) | 94% (84–98%) | 0.27 | 67% (40–86%) | 78% (73–83%) | 5.17 (1.71–15.58) | 0.71 (0.53–0.95) |
| Cutoff < 4 | ||||||||
| Total | 481 | 58% (51–66%) | 74% (69–79%) | 0.32 | 57% (52–63%) | 75% (71–78%) | 2.25 (1.79–2.83) | 0.56 (0.47–0.68) |
| No education | 11 | 75% (19–99%) | 43% (10–82%) | 0.18 | 43% (24–64%) | 75% (31–95%) | 1.31 (0.56–3.09) | 0.58 (0.09–3.90) |
| Low education | 129 | 74% (62–84%) | 62% (48–74%) | 0.36 | 69% (61–76%) | 67% (57–76%) | 1.93 (1.36–2.74) | 0.42 (0.27–0.66) |
| Middle education | 255 | 51% (39–62%) | 77% (70–83%) | 0.28 | 52% (43–60%) | 76% (72–80%) | 2.23 (1.58–3.16) | 0.64 (0.51–0.81) |
| High education | 86 | 38% (19–59%) | 81% (69–90%) | 0.19 | 42% (27–61%) | 77% (71–82%) | 1.94 (0.94–4.00) | 0.78 (0.56–1.08) |
| Variable | B 1 | SE B 2 | Wald Test | p | OR 3 (95% CI 4) |
|---|---|---|---|---|---|
| CDT score (the dependent variable) < 3 | |||||
| Age | 0.050 | 0.015 | 10.649 | 0.001 | 1.051 (1.020–1.083) |
| Gender | 0.083 | 0.234 | 0.127 | 0.722 | 1.087 (0.687–1.721) |
| Ethnicity | 0.065 | 0.057 | 1.309 | 0.252 | 1.067 (0.955–1.192) |
| Educational level | −0.493 | 0.162 | 9.288 | 0.002 | 0.611 (0.445–0.839) |
| Constant | −4.602 | 1.298 | 12.570 | <0.001 | 0.010 |
| CDT score (the dependent variable) < 4 | |||||
| Age | 0.041 | 0.013 | 9.821 | 0.002 | 1.041 (1.015–1.068) |
| Gender | −0.168 | 0.205 | 0.670 | 0.413 | 0.846 (0.566–1.263) |
| Ethnicity | 0.112 | 0.050 | 5.069 | 0.024 | 1.119 (1.015–1.234) |
| Educational level | −0.752 | 0.144 | 27.194 | <0.001 | 0.472 (0.356–0.626) |
| Constant | −2.559 | 1.090 | 5.507 | 0.019 | |
3.2. Clock Drawing Test Performance for Patients with and Without Dementia per Educational Level
3.3. Error Analysis
4. Discussion
4.1. Summary of Findings and Comparison to Literature
4.2. Strengths and Limitations
4.3. Implications for Research and Practice
5. Conclusions
Supplementary Materials
Author Contributions
Funding
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
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| Quantitative Analyses | |||||
|---|---|---|---|---|---|
| Clinical Diagnosis | |||||
| No Cognitive Impairment | MCI 1 | Dementia | Other Diagnosis 2 | Total | |
| Table 2 | N = 130 | N = 171 | N = 180 | N = 22 | 503 |
| Figure 2 Boxplot CDT score per education group | N = 301 | N = 180 | N = 22 not included | 481 | |
| Table 3 Sensitivity specificity | N = 301 | N = 180 | N = 22 not included | 481 | |
| Table 4 Logistic regression | N = 481 | N = 22 not included | 481 | ||
| Qualitative Analyses | |||||
| No and low education | 56 | 55 | N = 22 not included | 185 | |
| Middle or High education | N = 256 not included | 74 | N = 22 not included | ||
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Boots-van der Heiden, J.; van Campen, J.; Kooistra, T.; van de Vorst, I.; Goudsmit, M. The Clock Drawing Test: A Valid Screening Instrument for Dementia Detection in Low-Educated Patients? Geriatrics 2025, 10, 164. https://doi.org/10.3390/geriatrics10060164
Boots-van der Heiden J, van Campen J, Kooistra T, van de Vorst I, Goudsmit M. The Clock Drawing Test: A Valid Screening Instrument for Dementia Detection in Low-Educated Patients? Geriatrics. 2025; 10(6):164. https://doi.org/10.3390/geriatrics10060164
Chicago/Turabian StyleBoots-van der Heiden, Janique, Jos van Campen, Tessa Kooistra, Irene van de Vorst, and Miriam Goudsmit. 2025. "The Clock Drawing Test: A Valid Screening Instrument for Dementia Detection in Low-Educated Patients?" Geriatrics 10, no. 6: 164. https://doi.org/10.3390/geriatrics10060164
APA StyleBoots-van der Heiden, J., van Campen, J., Kooistra, T., van de Vorst, I., & Goudsmit, M. (2025). The Clock Drawing Test: A Valid Screening Instrument for Dementia Detection in Low-Educated Patients? Geriatrics, 10(6), 164. https://doi.org/10.3390/geriatrics10060164

