Next Article in Journal
Guiding Device for the Patellar Cut in Total Knee Arthroplasty: Design and Validation
Previous Article in Journal
A Cardiac Cell Outgrowth Assay for Evaluating Drug Compounds Using a Cardiac Spheroid-on-a-Chip Device
Article

Anti-RSV Peptide-Loaded Liposomes for the Inhibition of Respiratory Syncytial Virus †

1
Center for NanoBiotechnology Research, Alabama State University, Montgomery, AL 36016, USA
2
Aston Pharmacy School, Life and Health Sciences, Aston University, Birmingham B4 7ET, UK
3
Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, 161 Cathedral Street, Glasgow G4 0RE, UK
*
Author to whom correspondence should be addressed.
This paper is an extended version of our paper published in conference proceedings of TechConnect, 2017
Bioengineering 2018, 5(2), 37; https://doi.org/10.3390/bioengineering5020037
Received: 5 February 2018 / Revised: 29 April 2018 / Accepted: 7 May 2018 / Published: 9 May 2018
Although respiratory syncytial virus (RSV) is one of the leading causes of acute respiratory tract infection in infants and adults, effective treatment options remain limited. To circumvent this issue, there is a novel approach, namely, the development of multifunctional liposomes for the delivery of anti RSV-peptides. While most of the peptides that are used for loading with the particulate delivery systems are the penetrating peptides, an alternative approach is the development of liposome-peptide systems, which are loaded with an RSV fusion peptide (RF-482), which has been designed to inhibit the RSV fusion and block infection. The results of this work have revealed that the liposomes themselves can serve as potential RSV inhibitors, whilst the anti-RSV-peptide with liposomes can significantly increase the RSV inhibition when compared with the anti-RSV peptide alone. View Full-Text
Keywords: liposomes; respiratory syncytial virus; peptide; hydrophilic liposomes; respiratory syncytial virus; peptide; hydrophilic
Show Figures

Figure 1

MDPI and ACS Style

Joshi, S.; Chaudhari, A.A.; Dennis, V.; Kirby, D.J.; Perrie, Y.; Singh, S.R. Anti-RSV Peptide-Loaded Liposomes for the Inhibition of Respiratory Syncytial Virus. Bioengineering 2018, 5, 37. https://doi.org/10.3390/bioengineering5020037

AMA Style

Joshi S, Chaudhari AA, Dennis V, Kirby DJ, Perrie Y, Singh SR. Anti-RSV Peptide-Loaded Liposomes for the Inhibition of Respiratory Syncytial Virus. Bioengineering. 2018; 5(2):37. https://doi.org/10.3390/bioengineering5020037

Chicago/Turabian Style

Joshi, Sameer, Atul A. Chaudhari, Vida Dennis, Daniel J. Kirby, Yvonne Perrie, and Shree R. Singh. 2018. "Anti-RSV Peptide-Loaded Liposomes for the Inhibition of Respiratory Syncytial Virus" Bioengineering 5, no. 2: 37. https://doi.org/10.3390/bioengineering5020037

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop