Tumor Microenvironment on a Chip: The Progress and Future Perspective
George W. Woodruff School of Mechanical Engineering, Georgia Institute of Technology, Atlanta, GA 30332, USA
School of Mechanical and Aerospace Engineering, Seoul National University, Seoul 151-744, Korea
Parker H. Petit Institute for Bioengineering and Bioscience, Georgia Institute of Technology, Atlanta, GA 30332, USA
Institute for Electronics and Nanotechnology, Georgia Institute of Technology, Atlanta, GA 30332, USA
Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology, Atlanta, GA 30332, USA
Author to whom correspondence should be addressed.
Academic Editor: Hyun Jung Kim
Bioengineering 2017, 4(3), 64; https://doi.org/10.3390/bioengineering4030064
Received: 27 May 2017 / Revised: 17 July 2017 / Accepted: 19 July 2017 / Published: 21 July 2017
(This article belongs to the Special Issue Human Organs-on-Chips for In Vitro Disease Models)
Tumors develop in intricate microenvironments required for their sustained growth, invasion, and metastasis. The tumor microenvironment plays a critical role in the malignant or drug resistant nature of tumors, becoming a promising therapeutic target. Microengineered physiological systems capable of mimicking tumor environments are one emerging platform that allows for quantitative and reproducible characterization of tumor responses with pathophysiological relevance. This review highlights the recent advancements of engineered tumor microenvironment systems that enable the unprecedented mechanistic examination of cancer progression and metastasis. We discuss the progress and future perspective of these microengineered biomimetic approaches for anticancer drug prescreening applications.