Tumor Microenvironment on a Chip: The Progress and Future Perspective

Ahn, Jungho; Sei, Yoshitaka J.; Jeon, Noo Li; Kim, YongTae

doi:10.3390/bioengineering4030064

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Tumor Microenvironment on a Chip: The Progress and Future Perspective

by

Jungho Ahn

^1,2,

Yoshitaka J. Sei

^1,3,

Noo Li Jeon

² and

YongTae Kim

^1,3,4,5,*

¹

George W. Woodruff School of Mechanical Engineering, Georgia Institute of Technology, Atlanta, GA 30332, USA

²

School of Mechanical and Aerospace Engineering, Seoul National University, Seoul 151-744, Korea

³

Parker H. Petit Institute for Bioengineering and Bioscience, Georgia Institute of Technology, Atlanta, GA 30332, USA

⁴

Institute for Electronics and Nanotechnology, Georgia Institute of Technology, Atlanta, GA 30332, USA

⁵

Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology, Atlanta, GA 30332, USA

^*

Author to whom correspondence should be addressed.

Bioengineering 2017, 4(3), 64; https://doi.org/10.3390/bioengineering4030064

Submission received: 27 May 2017 / Revised: 17 July 2017 / Accepted: 19 July 2017 / Published: 21 July 2017

(This article belongs to the Special Issue Human Organs-on-Chips for In Vitro Disease Models)

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Abstract

Tumors develop in intricate microenvironments required for their sustained growth, invasion, and metastasis. The tumor microenvironment plays a critical role in the malignant or drug resistant nature of tumors, becoming a promising therapeutic target. Microengineered physiological systems capable of mimicking tumor environments are one emerging platform that allows for quantitative and reproducible characterization of tumor responses with pathophysiological relevance. This review highlights the recent advancements of engineered tumor microenvironment systems that enable the unprecedented mechanistic examination of cancer progression and metastasis. We discuss the progress and future perspective of these microengineered biomimetic approaches for anticancer drug prescreening applications.

Keywords: organ-on-a-chip; microfluidics; in vitro disease models; tumor microenvironment; drug screening; nanomedicine

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MDPI and ACS Style

Ahn, J.; Sei, Y.J.; Jeon, N.L.; Kim, Y. Tumor Microenvironment on a Chip: The Progress and Future Perspective. Bioengineering 2017, 4, 64. https://doi.org/10.3390/bioengineering4030064

AMA Style

Ahn J, Sei YJ, Jeon NL, Kim Y. Tumor Microenvironment on a Chip: The Progress and Future Perspective. Bioengineering. 2017; 4(3):64. https://doi.org/10.3390/bioengineering4030064

Chicago/Turabian Style

Ahn, Jungho, Yoshitaka J. Sei, Noo Li Jeon, and YongTae Kim. 2017. "Tumor Microenvironment on a Chip: The Progress and Future Perspective" Bioengineering 4, no. 3: 64. https://doi.org/10.3390/bioengineering4030064

APA Style

Ahn, J., Sei, Y. J., Jeon, N. L., & Kim, Y. (2017). Tumor Microenvironment on a Chip: The Progress and Future Perspective. Bioengineering, 4(3), 64. https://doi.org/10.3390/bioengineering4030064

Note that from the first issue of 2016, this journal uses article numbers instead of page numbers. See further details here.

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Tumor Microenvironment on a Chip: The Progress and Future Perspective

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