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Open AccessReview

Tumor Microenvironment on a Chip: The Progress and Future Perspective

by 1,2, 1,3, 2 and 1,3,4,5,*
1
George W. Woodruff School of Mechanical Engineering, Georgia Institute of Technology, Atlanta, GA 30332, USA
2
School of Mechanical and Aerospace Engineering, Seoul National University, Seoul 151-744, Korea
3
Parker H. Petit Institute for Bioengineering and Bioscience, Georgia Institute of Technology, Atlanta, GA 30332, USA
4
Institute for Electronics and Nanotechnology, Georgia Institute of Technology, Atlanta, GA 30332, USA
5
Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology, Atlanta, GA 30332, USA
*
Author to whom correspondence should be addressed.
Academic Editor: Hyun Jung Kim
Bioengineering 2017, 4(3), 64; https://doi.org/10.3390/bioengineering4030064
Received: 27 May 2017 / Revised: 17 July 2017 / Accepted: 19 July 2017 / Published: 21 July 2017
(This article belongs to the Special Issue Human Organs-on-Chips for In Vitro Disease Models)
Tumors develop in intricate microenvironments required for their sustained growth, invasion, and metastasis. The tumor microenvironment plays a critical role in the malignant or drug resistant nature of tumors, becoming a promising therapeutic target. Microengineered physiological systems capable of mimicking tumor environments are one emerging platform that allows for quantitative and reproducible characterization of tumor responses with pathophysiological relevance. This review highlights the recent advancements of engineered tumor microenvironment systems that enable the unprecedented mechanistic examination of cancer progression and metastasis. We discuss the progress and future perspective of these microengineered biomimetic approaches for anticancer drug prescreening applications. View Full-Text
Keywords: organ-on-a-chip; microfluidics; in vitro disease models; tumor microenvironment; drug screening; nanomedicine organ-on-a-chip; microfluidics; in vitro disease models; tumor microenvironment; drug screening; nanomedicine
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MDPI and ACS Style

Ahn, J.; Sei, Y.J.; Jeon, N.L.; Kim, Y. Tumor Microenvironment on a Chip: The Progress and Future Perspective. Bioengineering 2017, 4, 64. https://doi.org/10.3390/bioengineering4030064

AMA Style

Ahn J, Sei YJ, Jeon NL, Kim Y. Tumor Microenvironment on a Chip: The Progress and Future Perspective. Bioengineering. 2017; 4(3):64. https://doi.org/10.3390/bioengineering4030064

Chicago/Turabian Style

Ahn, Jungho; Sei, Yoshitaka J.; Jeon, Noo L.; Kim, YongTae. 2017. "Tumor Microenvironment on a Chip: The Progress and Future Perspective" Bioengineering 4, no. 3: 64. https://doi.org/10.3390/bioengineering4030064

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