Next Article in Journal
Hypoxic Three-Dimensional Scaffold-Free Aggregate Cultivation of Mesenchymal Stem Cells in a Stirred Tank Reactor
Next Article in Special Issue
Three-Dimensional Culture Model of Skeletal Muscle Tissue with Atrophy Induced by Dexamethasone
Previous Article in Journal
OpenDrop: An Integrated Do-It-Yourself Platform for Personal Use of Biochips
Previous Article in Special Issue
The Role of Microfluidics for Organ on Chip Simulations
Open AccessReview

Microtechnology-Based Multi-Organ Models

School of Chemical and Biological Engineering, Seoul National University, Seoul 151-742, Korea
Department of Chemical Engineering, Hongik University, Seoul 121-791, Korea
Author to whom correspondence should be addressed.
Academic Editor: Hyun Jung Kim
Bioengineering 2017, 4(2), 46;
Received: 19 March 2017 / Revised: 17 May 2017 / Accepted: 18 May 2017 / Published: 21 May 2017
(This article belongs to the Special Issue Human Organs-on-Chips for In Vitro Disease Models)
PDF [2340 KB, uploaded 21 May 2017]


Drugs affect the human body through absorption, distribution, metabolism, and elimination (ADME) processes. Due to their importance, the ADME processes need to be studied to determine the efficacy and side effects of drugs. Various in vitro model systems have been developed and used to realize the ADME processes. However, conventional model systems have failed to simulate the ADME processes because they are different from in vivo, which has resulted in a high attrition rate of drugs and a decrease in the productivity of new drug development. Recently, a microtechnology-based in vitro system called “organ-on-a-chip” has been gaining attention, with more realistic cell behavior and physiological reactions, capable of better simulating the in vivo environment. Furthermore, multi-organ-on-a-chip models that can provide information on the interaction between the organs have been developed. The ultimate goal is the development of a “body-on-a-chip”, which can act as a whole body model. In this review, we introduce and summarize the current progress in the development of multi-organ models as a foundation for the development of body-on-a-chip. View Full-Text
Keywords: microtechnology; in vitro models; multi-organ chip; multiple organ interaction; microfluidics microtechnology; in vitro models; multi-organ chip; multiple organ interaction; microfluidics

Graphical abstract

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

Share & Cite This Article

MDPI and ACS Style

Lee, S.H.; Sung, J.H. Microtechnology-Based Multi-Organ Models. Bioengineering 2017, 4, 46.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics



[Return to top]
Bioengineering EISSN 2306-5354 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top