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3D Printing of Organs-On-Chips
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The Role of Microfluidics for Organ on Chip Simulations

Department of Biomedical Engineering, Dalian University of Technology, Dalian 116024, Liaoning Province, China
Dalian Institute of Maternal and Child Health Care. Dalian 116024, Liaoning Province, China
Author to whom correspondence should be addressed.
Academic Editor: Hyun Jung Kim
Bioengineering 2017, 4(2), 39;
Received: 24 March 2017 / Revised: 1 May 2017 / Accepted: 2 May 2017 / Published: 4 May 2017
(This article belongs to the Special Issue Human Organs-on-Chips for In Vitro Disease Models)
A multichannel three-dimensional chip of a microfluidic cell culture which enables the simulation of organs is called an “organ on a chip” (OC). With the integration of many other technologies, OCs have been mimicking organs, substituting animal models, and diminishing the time and cost of experiments which is better than the preceding conventional in vitro models, which make them imperative tools for finding functional properties, pathological states, and developmental studies of organs. In this review, recent progress regarding microfluidic devices and their applications in cell cultures is discussed to explain the advantages and limitations of these systems. Microfluidics is not a solution but only an approach to create a controlled environment, however, other supporting technologies are needed, depending upon what is intended to be achieved. Microfluidic platforms can be integrated with additional technologies to enhance the organ on chip simulations. Besides, new directions and areas are mentioned for interested researchers in this field, and future challenges regarding the simulation of OCs are also discussed, which will make microfluidics more accurate and beneficial for biological applications. View Full-Text
Keywords: Microfluidics; 3D biopringting; Bioengineering; Biosensors; Microbiome Microfluidics; 3D biopringting; Bioengineering; Biosensors; Microbiome
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MDPI and ACS Style

Aziz, A.U.R.; Geng, C.; Fu, M.; Yu, X.; Qin, K.; Liu, B. The Role of Microfluidics for Organ on Chip Simulations. Bioengineering 2017, 4, 39.

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