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Bioengineering 2016, 3(1), 1;

Sustained Release of Antibacterial Agents from Doped Halloysite Nanotubes

Center for Biomedical Engineering and Rehabilitation Science, Louisiana Tech University, Ruston, LA 71272, USA
Wayne State University, St. John Hospital & Medical Center, 22101 Moross Rd, Detroit, MI 48236, USA
School of Biological Sciences, Louisiana Tech University, Ruston, LA 1272, USA
Author to whom correspondence should be addressed.
Academic Editor: Ali Khademhosseini
Received: 30 August 2015 / Revised: 16 November 2015 / Accepted: 16 December 2015 / Published: 23 December 2015
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The use of nanomaterials for improving drug delivery methods has been shown to be advantageous technically and viable economically. This study employed the use of halloysite nanotubes (HNTs) as nanocontainers, as well as enhancers of structural integrity in electrospun poly-e-caprolactone (PCL) scaffolds. HNTs were loaded with amoxicillin, Brilliant Green, chlorhexidine, doxycycline, gentamicin sulfate, iodine, and potassium calvulanate and release profiles assessed. Selected doped halloysite nanotubes (containing either Brilliant Green, amoxicillin and potassium calvulanate) were then mixed with poly-e-caprolactone (PLC) using the electrospinning method and woven into random and oriented-fibered nanocomposite mats. The rate of drug release from HNTs, HNTs/PCL nanocomposites, and their effect on inhibiting bacterial growth was investigated. Release profiles from nanocomposite mats showed a pattern of sustained release for all bacterial agents. Nanocomposites were able to inhibit bacterial growth for up to one-month with only a slight decrease in bacterial growth inhibition. We propose that halloysite doped nanotubes have the potential for use in a variety of medical applications including sutures and surgical dressings, without compromising material properties. View Full-Text
Keywords: antiseptics; antibiotics; drug release; halloysite nanotubes; nanocontainers; poly-e-caprolactone; nanocomposite mats antiseptics; antibiotics; drug release; halloysite nanotubes; nanocontainers; poly-e-caprolactone; nanocomposite mats

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Patel, S.; Jammalamadaka, U.; Sun, L.; Tappa, K.; Mills, D.K. Sustained Release of Antibacterial Agents from Doped Halloysite Nanotubes. Bioengineering 2016, 3, 1.

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